Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (3): 838-846.DOI: 10.6023/cjoc202108030 Previous Articles     Next Articles


基于原位捕获异腈的Ugi四组分反应及其后修饰串联反应: 一锅法合成含氮杂环化合物

罗享豪a, 谢益碧a, 黄年玉b, 王龙a,c,*()   

  1. a 三峡大学材料与化工学院 无机非金属晶体与能量转换材料重点实验室 湖北宜昌 443002
    b 三峡大学生物与制药学院 天然产物研究与利用湖北省重点实验室 湖北宜昌 443002
    c 湖北三峡实验室 湖北宜昌 443007
  • 收稿日期:2021-08-18 修回日期:2021-10-08 发布日期:2021-11-09
  • 通讯作者: 王龙
  • 基金资助:
    国家自然科学基金(21602123); 高等学校学科创新引智计划(111计划)(D20015)

Ugi Four-Component Reaction Based on in-situ Capture of Isocyanide and Post-Modification Tandem Reaction: One-Pot Synthesis of Nitrogen Heterocycles

Xianghao Luoa, Yibi Xiea, Nianyu Huangb, Long Wanga,c()   

  1. a Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, Hubei 443002
    b Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Science
    c China Three Gorges University, Yichang, Hubei 443007
  • Received:2021-08-18 Revised:2021-10-08 Published:2021-11-09
  • Contact: Long Wang
  • Supported by:
    National Natural Science Foundation of China(21602123); Program of Introducing Talents of Discipline to Universities (111 Project)(D20015)

A novel strategy of Ugi four-component and post-modification tandem reaction based on in-situ capture of isocyanide is reported in this paper. According to this reaction strategy, the isocyanide was prepared in situ and immediately captured to participate in Ugi four-component reaction and the subsequent modification tandem reaction. Compared with the previous reports, based on in-situ capture of isocyanide was realized in the Ugi four-component reaction and post-modification tandem reaction, which solved the problems of isocyanide instability, high toxicity and unfriendly to the environment in the reaction. Mild reaction system conditions and simplified preparation method provide a novel green and pollution-free strategy for the tandem reaction of Ugi four-component and post modification series reaction with isocyanide.

Key words: in-situ capture of isocyanide, Ugi four-component reaction, post-modification tandem reaction, green isocyanide chemistry, one-pot synthesis