Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (12): 4535-4553.DOI: 10.6023/cjoc202109007 Previous Articles     Next Articles

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α,β-不饱和硝酮的合成及其应用的研究进展

邹宁a, 覃小婷a, 王治新a, 石维敏b,*(), 莫冬亮a,*()   

  1. a 广西师范大学化学与药学学院 省部共建药用资源化学与药物分子工程国家重点实验室 广西桂林 541004
    b 广西科技大学医学部药学系 广西柳州 545006
  • 收稿日期:2021-09-03 修回日期:2021-10-30 发布日期:2021-11-09
  • 通讯作者: 石维敏, 莫冬亮
  • 基金资助:
    国家自然科学基金(21871062); 国家自然科学基金(22071035); 广西省自然科学基金(2018GXNSFAA281329); 广西教育厅研究生创新计划(YCBZ2021039); 广西高校千名中青年骨干教师培育计划资助项目

Advances on the Synthesis and Application of α,β-Unsaturated Nitrones

Ning Zoua, Xiaoting Qina, Zhixin Wanga, Weimin Shib(), Dongliang Moa()   

  1. a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, Guangxi 541004
    b School of Medicine, Guangxi University of Science and Technology, Liuzhou, Guangxi 545006
  • Received:2021-09-03 Revised:2021-10-30 Published:2021-11-09
  • Contact: Weimin Shi, Dongliang Mo
  • Supported by:
    National Natural Science Foundation of China(21871062); National Natural Science Foundation of China(22071035); Natural Science Foundation of Guangxi Province(2018GXNSFAA281329); Graduate Innovation Project of Guangxi Education(YCBZ2021039); “One thousand Young and Middle-Aged College and University Backbone Teachers Cultivation Program” of Guangxi

Nitrones, served as one of the most important 1,3-dipoles in organic synthetic chemistry, can participate in various organic synthetic reactions to synthesize various heterocyclic compounds, such as nucleophilic addition, cycloaddition reaction, rearrangement reaction, C—H bond activation, etc. They are very important organic building blocks for the further construction of complex molecules. In recent years, α,β-unsaturated nitrone has attracted widespread attention from synthetic chemists because of its α,β-unsaturated bond containing rich chemical transformations, and can take part in various new chemical conversions to construct new structural heterocyclic compounds. The new strategies for the preparation of α,β-unsaturated nitrones in the past ten years, and their applications to construct nitrogen heterocyclic compounds, including O-transfer reaction, addition of nucleophiles and radical reagents, and various cycloaddition reactions, are reviewed.

Key words: α,β-unsaturated nitrone, cycloaddition reaction, 1,3-dipole, N-heterocyclic compound, cascade reaction