Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (9): 2605-2639.DOI: 10.6023/cjoc202203037 Previous Articles     Next Articles



赵晓正a, 凌琴琴a, 曹桂妍a, 火星b, 赵小龙a, 苏瀛鹏a,*()   

  1. a 西北师范大学化学化工学院 兰州 730030
    b 兰州大学化学化工学院 兰州 730000
  • 收稿日期:2022-03-20 修回日期:2022-06-12 发布日期:2022-06-22
  • 通讯作者: 苏瀛鹏
  • 基金资助:
    国家自然科学基金(21961034); 国家自然科学基金(21502154); 国家自然科学基金(21362033); 甘肃省科技计划(21JR1RA232); 甘肃省高等学校产业支撑计划(2021CYZC-17)

Research Progress in the Cyclization Reactions with Propargyl Alcohols

Xiaozheng Zhaoa, Qinqin Linga, Guiyan Caoa, Xing Huob, Xiaolong Zhaoa, Yingpeng Sua()   

  1. a College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
    b College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000
  • Received:2022-03-20 Revised:2022-06-12 Published:2022-06-22
  • Contact: Yingpeng Su
  • Supported by:
    National Natural Science Foundation of China(21961034); National Natural Science Foundation of China(21502154); National Natural Science Foundation of China(21362033); Gansu Provincial Science and Technology Program(21JR1RA232); Industrial Support Program of Gansu Province for Colleges(2021CYZC-17)

Propargyl alcohols as a classical bifunctional group compounds possess alcohol hydroxyl group and carbon-carbon triple bond. Due to their special structure, they show unique reaction characteristics, and are employed in reactions via activating its alcoholic hydroxyl group or triple bond. The most typical reaction for propargyl alcohols is various cyclization reactions with different compounds to assemble a richer variety of cyclized compounds such as cyclopentene, pyrrole, furan, cyclic carbonate, pyran, pyridine and azepine cyclic compounds. The recent research progress in the cyclization reaction of propargyl alcohols with various compounds, including [3+2], [2+3], [3+3], [4+2], [2+4], [4+1], [3+4] and other types of cyclization reactions, is summarized.

Key words: propargyl alcohol, bifunctional group, alcohol hydroxyl, carbon-carbon triple bond, cascade reaction, cyclization