Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (12): 4758-4765.DOI: 10.6023/cjoc202109011 Previous Articles     Next Articles

ARTICLES

三甲基溴硅烷诱导的N-保护吲哚的区域选择性二聚合成2,3′-吲哚基二氢吲哚

唐爱玲, 金伟伟*(), 刘晨江*()   

  1. 新疆大学化学学院 乌鲁木齐 830046
  • 收稿日期:2021-09-06 修回日期:2021-10-19 发布日期:2021-11-03
  • 通讯作者: 金伟伟, 刘晨江
  • 基金资助:
    国家自然科学基金(21572195); 国家自然科学基金(21702175); 国家自然科学基金(21961037)

Trimethylsilyl Bromide-Induced Regioselective Dimerization of N-Protected Indoles to 2,3'-Linked Indolylindolines

Ailing Tang, Weiwei Jin(), Chenjiang Liu()   

  1. College of Chemistry, Xinjiang University, Urumqi 830046
  • Received:2021-09-06 Revised:2021-10-19 Published:2021-11-03
  • Contact: Weiwei Jin, Chenjiang Liu
  • Supported by:
    National Natural Science Foundation of China(21572195); National Natural Science Foundation of China(21702175); National Natural Science Foundation of China(21961037)

A dimerization of N-methylindoles by trimethylsilyl bromide promoted C—C bond cross coupling reactions is described. A series of 2,3'-linked indolylindolines are smoothly installed under mild reaction conditions with up to 95% yields. The gram scale reactions demonstrate the practicality of this protocol. The UV-vis absorption and fluorescence spectra properties of target products are preliminarily studied.

Key words: indole, dimerization, cross-coupling, indolylindoline