Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (12): 4067-4077.DOI: 10.6023/cjoc202208017 Previous Articles     Next Articles



朱玉溪a, 肖婷c, 夏冬b, 杨文超a,*()   

  1. a 扬州大学植物保护学院 江苏扬州 225009
    b 江苏医药职业学院药学院 江苏盐城 224005
    c 扬州大学广陵学院 江苏扬州 225009
  • 收稿日期:2022-08-15 修回日期:2022-09-26 发布日期:2022-10-24
  • 通讯作者: 杨文超
  • 基金资助:
    江苏省高校自然科学基金(22KJB150051); 江苏省高校自然科学基金(19KJB150020)

Recent Advances in the Decarboxylative Fluoroalkylation of Fluoroalkyl Carboxylic Acids

Yuxi Zhua, Ting Xiaoc, Dong Xiab, Wenchao Yanga()   

  1. a School of Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009
    b College of Pharmacy, Jiangsu Vocational College of Medicine, Yancheng, Jiangsu 224005
    c Guangling College, Yangzhou University, Yangzhou, Jiangsu 225009
  • Received:2022-08-15 Revised:2022-09-26 Published:2022-10-24
  • Contact: Wenchao Yang
  • Supported by:
    Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB150051); Natural Science Foundation of the Jiangsu Higher Education Institutions of China(19KJB150020)

Decarboxylation of fluoroalkyl carboxylic acid derivatives is an effective way to obtain fluoroalkyl radicals, which subsequently participates in the tandem and addition reactions of olefins, isonitriles and aromatic (hetero) rings, providing an important method to obtain divegent fluorine-containing molecules. A variety of fluoroalkyl cyclic compounds such as phenanthridines, dihydroflavonoid, quinolinones and indolones could be constructed using the tandem reaction initiated by fluoroalkyl radicals generated from fluoroalkyl carboxylic acids. The research progress of radical reactions induced by decarboxylation of fluoroalkyl carboxylic acids in recent years is summarized, which includes reaction design, reaction mechanism and outlook.

Key words: fluoroalkylation, decarboxylative reaction, carboxylic acid