The antitumor activity and the internal stress of partial conjugated five and/or six-member rings of natural terpenoid

Abstract

The chem. activity and the internal stress of a-methylenecyclopentanone of natural terpenoids (e.g., ent-kaurene and B-seco-kaurene extracted from Rabdosia) is discussed. It is suggested that the existence of interior stress of the mol. leads to an increase of chem. activity of these drugs and probably has a close relation to their antitumor activity.

Key words: LACTONES, ANTICARCINOGEN, SESQUITERPENE, TERPENE, ACTIVITY, STRUCTURE AND PROPERTY CORRELATION, DITERPENES, FIVE MEMBER RING HETEROCYCLIC COMPOUNDS, KAURENS

CLC Number:

O629

Cite this article

CHEN YUANZHU;WU CIWU;CHENG PEIYUAN. The antitumor activity and the internal stress of partial conjugated five and/or six-member rings of natural terpenoid[J]. Chin. J. Org. Chem., 1987, 7(1): 21-28.

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