Chin. J. Org. Chem. ›› 1988, Vol. 8 ›› Issue (1): 70-73. Previous Articles     Next Articles

顺-1-环己基-3-酰氨基-4-取代苯基-2-氮杂环丁酮的合成

谢伦嘉;毛文仁   

  1. 华西医科大学药化教研室
  • 发布日期:1988-02-25

Synthesis of cis-substituted azetidinones

XIE LUNJIA;MAO WENREN   

  • Published:1988-02-25

23 Novel monocyclic azetidinones were prepared by cyclization of Dane salt with substituted benzylidene aminocyclohexanes followed by a modified hydrolysis and amidation with corresponding acid chloride or acid and DCC. Compounds I (R = 2-, 4-Cl, 3,4-methylenedioxy) showed bacteriostatic and b-lactamaic inhibiting activity.

Key words: ANTIBIOTICS, AMIDES, BENZENE P, CYCLOHEXANE P, MONOKETONE, BETA LACTAM, AZETIDINE P

CLC Number: