Synthesis of ethyl 2, 3-dichloro-5-substituted-5, 8-dihydro-8-oxo- pyrido [2, 3-b] pyrazine-7-carboxylates

Chin. J. Org. Chem. ›› 1996, Vol. 16 ›› Issue (3): 261-266. Previous Articles Next Articles

Original Articles

2, 3-二氯-5-取代-5, 8-二氢-8-氧-吡啶并[2, 3-b)吡嗪-7-羧酸乙酯的合成

王海山;张致平

中国医学科学院医药生物技术研究所

发布日期:1996-06-25

Synthesis of ethyl 2, 3-dichloro-5-substituted-5, 8-dihydro-8-oxo- pyrido [2, 3-b] pyrazine-7-carboxylates

WANG HAISHAN;ZHANG ZHIPING

Published:1996-06-25

Abstract

3, 5, 6-Trichloro-2-cyanopyazine (6) was prepared by reaction of 3, 5, 6-trioxopiperazine-2-carboxamide (4) with PCl5-POCl3 and then was converted to methyl ester (7) which was further hydrolyzed to 3, 5, 6-trichloro-2-pyrazinecarboxyicacid (8). Two ethyl 2, 3-dichloro -5-substituted-5, 8-dihydro-8-oxo-pyrido [2, 3-b] pyrazine-7- carboxylates (11a~b) were synthesized starting from 8. The composition and structure of these compounds (5, 7~11) were established by their elemental analysis and NMR, MS and IR.

Key words: INFRARED SPECTROPHOTOMETRY, ANTISEPTICS, MASS SPECTROGRAPHY, FORMAMIDE, PROTON MAGNETIC RESONANCE SPECTROMETRY, DRUGS

CLC Number:

R914

Cite this article

WANG HAISHAN;ZHANG ZHIPING. Synthesis of ethyl 2, 3-dichloro-5-substituted-5, 8-dihydro-8-oxo- pyrido [2, 3-b] pyrazine-7-carboxylates[J]. Chin. J. Org. Chem., 1996, 16(3): 261-266.

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2, 3-二氯-5-取代-5, 8-二氢-8-氧-吡啶并[2, 3-b)吡嗪-7-羧酸乙酯的合成

Synthesis of ethyl 2, 3-dichloro-5-substituted-5, 8-dihydro-8-oxo- pyrido [2, 3-b] pyrazine-7-carboxylates

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