Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (10): 1429-1433. Previous Articles     Next Articles




  1. (贵州大学精细化工研究开发中心 绿色农药和农业生物工程教育部重点实验室 贵阳 550025)
  • 收稿日期:2006-01-05 修回日期:2006-03-16 发布日期:2006-09-19
  • 通讯作者: 宋宝安

Synthesis and Anti-phosphorylation Activity of 4-Substitutedanilinoquinazoline Compounds

YANG Song,LIU Gang,SONG Bao-An*,JIN Lin-Hong
HU De-Yu,ZHANG Su-Mei   

  1. (Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for
    Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025)
  • Received:2006-01-05 Revised:2006-03-16 Published:2006-09-19
  • Contact: SONG Bao-An

Eight new 4-substitutedquinazoline compounds were synthesized by three-step reaction using 4-chloroquinazoline as starting material. The structures of the title compounds were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra. The results of bioassay showed that compound 1f had good antiproliferation activity against cancer cell PC3 with rate of 88.6% at the concentration of 1 μmol•L-1 and inhibits ERK (extracellular sig-nal-regulated kinase) phosphorylation in cells PC3 induced by EGFR (epidermal growth factor receptor).

Key words: biological activity, anti-phosphorylation, quinazoline