Chin. J. Org. Chem. ›› 2007, Vol. 27 ›› Issue (06): 685-695.     Next Articles

Review

抗HIV天然产物Calanolide A及其类似物的合成进展

杨光忠*,a,陈玉b   

  1. (a中南民族大学生命科学学院民族药物研究所 武昌 430074)
    (b中南民族大学化学与材料学院 武昌 430074)
  • 收稿日期:2006-05-08 修回日期:2006-08-29 发布日期:2007-05-21
  • 通讯作者: 杨光忠

Progress in Total Synthesis of Calanolide A and Its Analogues

YANG Guang-Zhong*,a, CHEN Yub   

  1. (a National Medicine Institute, College of Life Sciences, South-Central University for Nationalities, Wuhan 430074)
    (b College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan 430074)
  • Received:2006-05-08 Revised:2006-08-29 Published:2007-05-21
  • Contact: YANG Guang-Zhong

Calanolide A was a kind of pyranocoumarin which was isolated from Calophyllum genus plant. It showed strong inhibition against HIV-1-RT, and was a top lead compound of anti-HIV. In this paper, the to-tal synthesis of calanolide A and its analogues has been reviewed. Each synthetic route has been analyzed. Both merits and limitations of synthetic method have been discussed.

Key words: total synthesis, anti-HIV, calanolide A