A Novel Synthesis of Isoquinolone Derivatives

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (06): 894-897. Previous Articles Next Articles

Notes

异喹啉酮类衍生物的合成研究

谢宇*，胡金刚，洪小伟，魏娅，贾杰

南昌航空大学环境与化学工程学院南昌 330063

收稿日期:2009-05-31 修回日期:2009-11-02 发布日期:2010-01-06
通讯作者: 谢宇 E-mail:xieyu_121@sina.com
基金资助:
国家自然科学基金（20807021）;江西省自然科学基金（0620071）;航空高校基金（EA200502138）;国家级.国家自然科学基金

A Novel Synthesis of Isoquinolone Derivatives

XIE Yu, HU Jin-Gang, HONG Xiao-Wei, WEI Ya, JIA Jie

College of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063

Received:2009-05-31 Revised:2009-11-02 Published:2010-01-06

Abstract

1,2,3,4-Tetrahydroisoquinoline derivatives were synthesized from 2-(3-methoxyphenyl)ethy- lamine and ethyl chloroformate via the process of nucleophilic substitution, cyclization reaction and lithium aluminium hydride (LAH) reduction. The key step, cyclization reaction, was accomplished by using polyphoshponic acid (PPA) as a catalyst conveniently and effectively without any another catalyst for the first time. Moreover, a series of isoquinolone derivatives were synthesized.

Key words: 1,2,3,4-tetrahydroisoquinoline, cyclization reaction, polyphoshponic acid (PPA)

Cite this article

XIE Yu, HU Jin-Gang, HONG Xiao-Wei, WEI Ya, JIA Jie. A Novel Synthesis of Isoquinolone Derivatives[J]. Chin. J. Org. Chem., 2010, 30(06): 894-897.

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异喹啉酮类衍生物的合成研究

A Novel Synthesis of Isoquinolone Derivatives

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