Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (04): 453-465. Previous Articles     Next Articles

Reviews

氮自由基环化反应的新进展

徐小岚1,3,万薪2,耿烨2,张家松2,许华建*,2,3   

  1. (1安徽医科大学基础医学院 合肥 230032)
    (2合肥工业大学化学工程学院 合肥 230009)
    (3可控化学与材料化工安徽省重点实验室 合肥 230009)
  • 收稿日期:2010-05-18 修回日期:2010-08-04 发布日期:2010-10-22
  • 通讯作者: 许华建 E-mail:hjxu@hfut.edu.cn
  • 基金资助:

    辅酶NADH模型物负氢转移机理及其在有机小分子催化中应用研究;辅酶NADH模型物在绿色有机合成中的应用研究

Recent Progress in Nitrogen-Centered Radical Cyclizations

Xu Xiaolan1,3 Wan Xin2 Geng Ye2 Zhang Jiasong2 Xu Huajian*,2,3   

  1. (1 College of Basic Medicine, Anhui Medical University, Hefei 230032)
    (2 School of Chemical and Engineering, Hefei University of Technology, Hefei 230009)
    (3 Anhui Key Laboratory of Controllable Chemistry Reaction & Material Chemical Engineering, Hefei 230009)
  • Received:2010-05-18 Revised:2010-08-04 Published:2010-10-22
  • Contact: XU Hua-Jian E-mail:hjxu@hfut.edu.cn

Radical reactions were applied widely in organic synthesis about three decades ago, but most of the synthetic applications have concerned on carbon-centered radicals, while heteroatom-centered radicals have received much less scrutiny. The cyclizations of nitrogen radicals in organic synthesis have gained increasing attentions in the past few years, because it is very important for synthesizing N-heterocycle compounds, such as lactams, pyrrolidines, alkaloids and so on. This review describes the recent progress of nitrogen radicals on the cyclization to form various N-heterocycles.

Key words: radical reaction, organic synthesis, nitrogen radical, cyclization, N-heterocycle