Microwave Promoted Synthesis of Acyclic Purine Nucleosides

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (10): 1613-1617. Previous Articles Next Articles

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微波促进的非环核苷类化合物的合成

牛红英^1,2，袁腾飞¹，渠桂荣*^,1，李德阳¹，毛润泽¹，金鑫¹，杨西宁¹，郭海明*^,1

(¹河南师范大学化学与环境科学学院绿色化学介质与反应教育部重点实验室新乡 453007)
(²河南科技学院化学化工学院新乡 453003)

收稿日期:2011-02-16 修回日期:2011-04-15 发布日期:2011-05-09
通讯作者: 郭海明 E-mail:ghm@htu.cn

Microwave Promoted Synthesis of Acyclic Purine Nucleosides

Niu Hongying^1,2 Yuan Tengfei¹ Qu Guirong*^,1 Li Deyang¹ Mao Runze¹ Jin Xin¹ Yang Xining¹ Guo Haiming*^,1

(¹Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007)
(²School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003)

Received:2011-02-16 Revised:2011-04-15 Published:2011-05-09
Contact: Hai-Ming GUO E-mail:ghm@htu.cn

Acyclic purine nucleosides were synthesized in good to high yields via Michael addition reaction of purine bases and α,β-unsaturated aldehydes under microwave irradiation and reduced by NaBH₄ in situ. The structures of all compounds are characterized by NMR and HRMS techniques.

Key words: acyclic nucleoside, α,β-unsaturated aldehyde, Michael addition reaction, microwave, triethyl-amine

Cite this article

NIU Hong-Ying, YUAN Teng-Fei, QU Gui-Rong, LI De-Yang, MAO Run-Ze, JIN Xin, YANG Xi-Ning, GUO Hai-Ming. Microwave Promoted Synthesis of Acyclic Purine Nucleosides[J]. Chin. J. Org. Chem., 2011, 31(10): 1613-1617.

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微波促进的非环核苷类化合物的合成

Microwave Promoted Synthesis of Acyclic Purine Nucleosides

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