Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (4): 855-862.DOI: 10.6023/cjoc201709033 Previous Articles     Next Articles



林伟a, 胡秀秀a, 王雅珍a, 宋帅a, 张梦烨b, 史达清b   

  1. a 江苏理工学院化学与环境工程学院 常州 213001;
    b 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2017-09-21 修回日期:2017-11-09 发布日期:2017-12-01
  • 通讯作者: 林伟, 史达清;
  • 基金资助:


Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction

Lin Weia, Hu Xiuxiua, Wang Yazhena, Song Shuaia, Zhang Mengyeb, Shi Daqingb   

  1. a School of Chemistry and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001;
    b College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2017-09-21 Revised:2017-11-09 Published:2017-12-01
  • Contact: 10.6023/cjoc201709033;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21502074), the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions (No. 15KJA150006) and the College Students Practice Innovation Training Plan of Jiangsu Province (No. 201711463010Z).

The research of indoles has been one of the most active areas of heterocyclic chemistry. In particular, 3-substituted indole derivatives have received much attention as building blocks for the synthesis of many natural products and other biologically active compounds. In this article, an synthetic procedure for multi-substituted indole derivatives was successfully developed by a three-component reaction of phenylglyoxal monohydrate, aromatic amine and 4-hydroxycoumarin with a catalytic amount of trifluoroacetic acid under microwave irradiation conditions. This method has the advantages of simple operation, readily available raw materials, and high atom utilization.

Key words: indole, synthesis, three-component reaction, microwave