Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (08): 1448-1453. Previous Articles     Next Articles



马大友 ; 余聂芳*   

  1. 中南大学药学院 长沙 410013
  • 收稿日期:2007-09-17 修回日期:2007-12-14 发布日期:2008-08-18
  • 通讯作者: 余聂芳

Synthesis of Novel 2-(Substituted anilino)pyrimidine Derivatives

MA, Da-You; YU, Nie-Fang*   

  1. School of Pharmacy, Central South University, Changsha 410013
  • Received:2007-09-17 Revised:2007-12-14 Published:2008-08-18
  • Contact: YU, Nie-Fang

4-(m-Substituted phenyl)-2-choloro-pyrimidines were prepared by Suzuki coupling reaction of 3-hydroxyphenylboronic acid with 2,4-dichloropyrimidine followed by alkylation of the hydroxyl group, which were effectively aminated by arylamine under catalysis of Pd(PPh3)4/dppf. Three novel 2- 2-(substituted anilino)pyrimidine derivatives were thus conveniently synthesized. The structures of all the synthesized compounds were fully characterized by IR, 1H NMR, 13C NMR, mass spectra and elemental analysis.

Key words: dppf, 2-(substituted anilino)pyrimidine, coupling reaction, Pd(PPh3)4