Synthesis of Novel 2-(Substituted anilino)pyrimidine Derivatives

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (08): 1448-1453. Previous Articles Next Articles

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新型2-芳氨基嘧啶衍生物的合成

马大友 ; 余聂芳^*

中南大学药学院长沙 410013

收稿日期:2007-09-17 修回日期:2007-12-14 发布日期:2008-08-18
通讯作者: 余聂芳

Synthesis of Novel 2-(Substituted anilino)pyrimidine Derivatives

MA, Da-You; YU, Nie-Fang*

School of Pharmacy, Central South University, Changsha 410013

Received:2007-09-17 Revised:2007-12-14 Published:2008-08-18
Contact: YU, Nie-Fang

Abstract

4-(m-Substituted phenyl)-2-choloro-pyrimidines were prepared by Suzuki coupling reaction of 3-hydroxyphenylboronic acid with 2,4-dichloropyrimidine followed by alkylation of the hydroxyl group, which were effectively aminated by arylamine under catalysis of Pd(PPh3)4/dppf. Three novel 2- 2-(substituted anilino)pyrimidine derivatives were thus conveniently synthesized. The structures of all the synthesized compounds were fully characterized by IR, 1H NMR, 13C NMR, mass spectra and elemental analysis.

Key words: dppf, 2-(substituted anilino)pyrimidine, coupling reaction, Pd(PPh3)4

Cite this article

MA, Da-You; YU, Nie-Fang*. Synthesis of Novel 2-(Substituted anilino)pyrimidine Derivatives[J]. Chin. J. Org. Chem., 2008, 28(08): 1448-1453.

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新型2-芳氨基嘧啶衍生物的合成

Synthesis of Novel 2-(Substituted anilino)pyrimidine Derivatives

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