Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (06): 894-897. Previous Articles     Next Articles




  1. 南昌航空大学环境与化学工程学院 南昌 330063
  • 收稿日期:2009-05-31 修回日期:2009-11-02 发布日期:2010-01-06
  • 通讯作者: 谢宇
  • 基金资助:


A Novel Synthesis of Isoquinolone Derivatives

XIE Yu, HU Jin-Gang, HONG Xiao-Wei, WEI Ya, JIA Jie   

  1. College of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063
  • Received:2009-05-31 Revised:2009-11-02 Published:2010-01-06

1,2,3,4-Tetrahydroisoquinoline derivatives were synthesized from 2-(3-methoxyphenyl)ethy- lamine and ethyl chloroformate via the process of nucleophilic substitution, cyclization reaction and lithium aluminium hydride (LAH) reduction. The key step, cyclization reaction, was accomplished by using polyphoshponic acid (PPA) as a catalyst conveniently and effectively without any another catalyst for the first time. Moreover, a series of isoquinolone derivatives were synthesized.

Key words: 1,2,3,4-tetrahydroisoquinoline, cyclization reaction, polyphoshponic acid (PPA)