Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (3): 439-446.DOI: 10.6023/cjoc201511054 Previous Articles     Next Articles

Reviews

Jiadifenolide的合成研究进展

李林斌, 沈洋, 张延东   

  1. 厦门大学化学化工学院 福建省化学生物学重点实验室 厦门 361005
  • 收稿日期:2015-11-30 修回日期:2015-12-29 出版日期:2016-03-25 发布日期:2016-01-07
  • 通讯作者: 张延东 E-mail:ydzhang@xmu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 21142007, 21272194, 21572187, U1405228)、中央高校基本科研业务费专项资金(No. 20720160025)和教育部长江学者和创新团队发展计划资助项目.

Synthetic Progress of Jiadifenolide

Li Linbin, Shen Yang, Zhang Yandong   

  1. Department of Chemistry and Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005
  • Received:2015-11-30 Revised:2015-12-29 Online:2016-03-25 Published:2016-01-07
  • Supported by:

    Project supported by the National Natural Science Foundations of China (Nos. 21142007, 21272194, 21572187, U1405228), the Fundamental Research Funds for the Central Universities (No. 20720160025) and the Program for Changjiang Scholars and Innovative Research Team in University.

Jiadifenolide, a new seco-prezizaane-type sesquiterpenoid, was isolated from Chinese unique medicine Illicium jiadifengpi. It contains a highly oxygenated cagelike architecture with seven contiguous stereocenters. It displays potent neurotrophic activity at very low concentration and is regarded as a promising lead compound for developing drugs for neurodegenerative diseases. This review summarizes the synthetic efforts towards jiadifenolide in the last five years.

Key words: jiadifenolide, seco-prezizaane-type sesquiterpenoid, neurotrophic agent, neurodegenerative diseases, total synthesis