Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (4): 777-797.DOI: 10.6023/cjoc201610035 Previous Articles     Next Articles

REVIEW

一氧化氮供体化合物的合成方法研究进展

王兵a,b, 李娜a,b, 刘腾a,b, 王英爱a,b, 王晓静a,b, 孙捷a,b   

  1. a. 济南大学 山东省医学科学院 医学与生命科学学院 济南 250200;
    b. 山东省医学科学院药物研究所 国家卫生部生物技术药物重点实验室 山东省罕少见病重点实验室 济南 250062
  • 收稿日期:2016-10-21 修回日期:2016-12-29 出版日期:2017-04-25 发布日期:2017-01-20
  • 通讯作者: 王晓静, 孙捷 E-mail:xiaojing6@gmail.com;635775299@qq.com
  • 基金资助:

    山东省自然科学基金(No.ZR2015YL041)资助项目.

Research Progress on Synthesis of Nitric Oxide Donor Compounds

Wang Binga,b, Li Naa,b, Liu Tenga,b, Wang Ying'aia,b, Wang Xiaojinga,b, Sun Jiea,b   

  1. a. School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200;
    b. Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory for Rare & Uncommon Diseases of Shandong Province, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062
  • Received:2016-10-21 Revised:2016-12-29 Online:2017-04-25 Published:2017-01-20
  • Contact: 10.6023/cjoc201610035 E-mail:xiaojing6@gmail.com;635775299@qq.com
  • Supported by:

    Project supported by the Natural Science Foundation of Shandong Province (No. ZR2015YL041).

Nitric oxide as a biological messenger or effector molecule plays an important physiological role in the body. Owing to its various biological activities, it has received wide attention in clinical practice. Insufficient NO production in vivo is closely related with a variety of diseases. NO donor compounds can release NO in vivo to treat and prevent many diseases. With its wide application in medicine, the methods for the synthesis of NO donor compounds have attracted much attention of researchers. In this paper, the recent advances in the past 10 years in synthetic methods for NO donor compounds are reviewed.

Key words: nitric oxide donor, synthetic method, pharmacological activity