Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (4): 886-898.DOI: 10.6023/cjoc201910020 Previous Articles     Next Articles


徐鑫明,a, 李家柱a, 王祖利b   

  1. a 烟台大学化学化工学院 山东烟台 264005;
    b 青岛农业大学化学与药学院 山东青岛 266109
  • 收稿日期:2019-10-16 修回日期:2019-11-28 发布日期:2019-12-19
  • 通讯作者: 徐鑫明
  • 基金资助:

Recent Advances in Transition Metal-Free Sulfenylation of Indoles

Xu Xinming,a, Li Jiazhua, Wang Zulib   

  1. a College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005;
    b College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, Shandong 266109
  • Received:2019-10-16 Revised:2019-11-28 Published:2019-12-19
  • Supported by:
    Project supported by the Young Scholars Research Fund of Yantai University (No. HY19B06).

Recently, the direct sulfenylation of C——H bond for C——S formation under transition metal-free conditions has rapidly advanced and is employed for eco-friendly synthesis of sulfenylated natural or bioactive compounds with various sulfenylating reagents. In particular, the sulfenylation of indoles is considered to be the most important because it can lead to a new class of molecules displaying a broad spectrum of biological and pharmaceutical activities. The recent five-year progress in direct C——H bond sulfenylation of indoles under transition metal-free conditions is discussed and their mechanisms in detail are described.

Key words: sulfenylation, indoles, transition metal-free, reaction mechanism, synthetic method