Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (5): 1165-1172.DOI: 10.6023/cjoc201701043 Previous Articles     Next Articles



朱超泽, 冯见君, 张俊良   

  1. 华东师范大学化学与分子工程学院 上海 200062
  • 收稿日期:2017-01-21 修回日期:2017-02-16 发布日期:2017-02-20
  • 通讯作者: 冯见君,张俊良;
  • 基金资助:


Rhodium(Ⅰ)-Catalyzed Stereospecific [3+2] Cycloadditions of Vinylaziridines and Ynamides

Zhu Chaoze, Feng Jianjun, Zhang Junliang   

  1. School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062
  • Received:2017-01-21 Revised:2017-02-16 Published:2017-02-20
  • Contact: 10.6023/cjoc201701043;
  • Supported by:

    Project supported by the Shanghai Sailing Program (No. 15YF1403600) and the National Natural Science Foundation of China (Nos. 21602062, 21373088, 21425205).

The first rhodium-catalyzed stereospecific intermolecular [3+2] cycloaddition reaction of vinylaziridines with ynamides was realized. The salient features of the transformation include broad substrate scope, mild reaction condition, and simple operation. Moreover, the chirality of vinylaziridines can be completely transferred to the cycloadducts, representing an atom-economic and enantiospecific protocol for the construction of valuable 2-amino pyrroline derivatives.

Key words: transition-metal catalysis, cycloaddition, vinylaziridine, ynamides, nitrogen heterocycles