Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (7): 1740-1748.DOI: 10.6023/cjoc201801049 Previous Articles     Next Articles



谭家希, 郭也, 曾飞, 陈观荣, 谢龙勇, 何卫民   

  1. 湖南省银杏工程技术研究中心 湖南科技学院 永州 425100
  • 收稿日期:2018-01-31 修回日期:2018-03-18 发布日期:2018-03-29
  • 通讯作者: 何卫民
  • 基金资助:


Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates

Tan Jiaxi, Guo Ye, Zeng Fei, Chen Guanrong, Xie Longyong, He Weimin   

  1. Hunan Provincial Engineering Research Center for Ginkgo biloba, Hunan University of Science and Engineering, Yongzhou 425100
  • Received:2018-01-31 Revised:2018-03-18 Published:2018-03-29
  • Contact: 10.6023/cjoc201801049
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21602055, 21302048), the Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (No. 2012-318) and the Construct Program of the Key Discipline in Hunan Province.

A mild, general and efficient method for the direct synthesis of diverse amides from commercially available carboxylic acids and isothiocyanates has been developed. The strategy does not require stoichiometric amounts of coupling reagents or metal catalysts, and is especially for sterically hindered and electron-deficient secondary amides, which are otherwise challenging to synthesize.

Key words: amides, carboxylic acids, isothiocyanates, synthetic methods, electron-deficient amides