Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1354-1361.DOI: 10.6023/cjoc201810015 Previous Articles     Next Articles

Articles

通过氰基亚胺与香豆灵酸甲酯的1,3-偶极环加成反应合成二氢吡喃并吡唑酮

王博, 王奇君, 刘洪蕾, 廖健宁, 黄家兴, 郭红超   

  1. 中国农业大学应用化学系 北京 100193
  • 收稿日期:2018-10-14 修回日期:2018-12-27 出版日期:2019-05-25 发布日期:2019-02-19
  • 通讯作者: 黄家兴, 郭红超 E-mail:hchguo@cau.edu.cn;05084@cau.edu.cn
  • 基金资助:

    国家自然科学基金(No.21572264)资助项目.

Synthesis of Dihydropyrano[3,2-c]pyrazolone through 1,3-Dipolar Cycloaddition of Nitrilimines with Methyl Coumalate

Wang Bo, Wang Qijun, Liu Honglei, Liao Jianning, Huang Jiaxing, Guo Hongchao   

  1. Department of Applied Chemistry, China Agricultural University, Beijing 100193
  • Received:2018-10-14 Revised:2018-12-27 Online:2019-05-25 Published:2019-02-19
  • Contact: 10.6023/cjoc201810015 E-mail:hchguo@cau.edu.cn;05084@cau.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21572264).

The 1,3-dipolar cycloaddition of nitrilimines with methyl coumalate or pyranone worked efficiently in the presence of iPr2NEt under room temperature to give functionalized dihydropyrano[3,2-c]pyrazol-5(1H)-one derivatives in high to excellent yields with excellent diastereoselectivities.

Key words: cycloaddition, nitrilimine, coumalate, pyranone, pyrazoline