Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (9): 2811-2816.DOI: 10.6023/cjoc202005060 Previous Articles     Next Articles


韩光辉a,b, 任宇豪b, 范耀月b, 纪开龙b, 周彬b, 曹卫国a, 岳建民b   

  1. a 上海大学理学院化学系 上海 200444;
    b 中国科学院上海药物研究所 新药研究国家重点实验室 上海 201203
  • 收稿日期:2020-05-22 修回日期:2020-06-16 发布日期:2020-07-01
  • 通讯作者: 曹卫国, 岳建民;
  • 基金资助:

Diverse Diterpenoids from Microdesmis casearifolia

Han Guanghuia,b, Ren Yuhaob, Fan Yaoyueb, Ji Kailongb, Zhou Binb, Cao Weiguoa, Yue Jianminb   

  1. a Department of Chemistry, College of Science, Shanghai University, Shanghai 200444;
    b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203
  • Received:2020-05-22 Revised:2020-06-16 Published:2020-07-01
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21532007, 21772213), the Drug Innovation Major Project of China (No. 2018ZX09711001-001-005), the Biological Resources Program of Chinese Academy of Sciences (No. KFJ-BRP-008) and the Youth Innovation Promotion Association, Chinese Academy of Sciences.

Four new diterpenoids, casearoids A~D (1~4), including dolabrane, orosane, labdane, and cembrane, were isolated and characterized from Microdesmis casearifolia. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of these diterpenoids were established by analysis of the electronic circular dichroism (ECD) data.

Key words: Microdesmis casearifolia, Microdesmis genus, diterpenoid, casearoids A~D, spectroscopic analysis, electronic circular dichroism (ECD) analysis