Advanced in the Synthesis of Kaurane Diterpenoids

doi:10.6023/cjoc201509027

Abstract

Kaurane, especially ent-kaurane diterpenoids are integral parts of terpenoid natural products, and possess various bioactivities, including antibacterial, antitumor, antimalarial and antiviral activities. Additionally, as a result of intramolecular oxidations, cleavages and rearrangements, the tetracyclic ent-kaurane also shows attractive structural diversity. Hence, the total syntheses of ent-kauranes have evoked a great deal of interest in the synthetic community. This review presents the recent advances in the synthesis of ent-kaurane and kauranediterpenoids.

Key words: diterpenoids, ent-kaurane, total synthesis

Cite this article

Du Mingjun, Lei Xiaoguang. Advanced in the Synthesis of Kaurane Diterpenoids[J]. Chin. J. Org. Chem., 2015, 35(12): 2447-2464.

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贝壳杉烷型二萜合成进展