化学学报 ›› 1978, Vol. 36 ›› Issue (3): 199-206. 上一篇    下一篇

论文

丹参有效成分的研究——Ⅰ.丹参酮Ⅱ-A磺酸钠和次甲丹参醌的化学结构

钱名堃1, 杨保津1, 顾文华1, 陈政雄1, 陈馨德2, 叶秀琴2   

  1. 1. 中国科学院上海药物研究所;
    2. 上海中药三厂
  • 投稿日期:1977-11-28 发布日期:2013-06-03

STUDIES ON THE ACTIVE PRINCIPLES OF DAN-SHEN——Ⅰ.THE STRUCTURE OF SODIUM TANSHINONE Ⅱ-A SULFONATE AND METHYLENE TANSHINQUINONE

CHIEN MING-KUN1, YOUNG PAO-TSIN1, KU WEN-HUA1, CHEN ZHENG-XIONG1, CHEN HSING-TE2, YEH HSIU-CHIN2   

  1. 1. Shanghai Institute of Materia Medica, Academia Sinica;
    2. Shanghai No.3 Pharmaceutical Factory of Chinese Meteria Medica
  • Received:1977-11-28 Published:2013-06-03

丹参(Salvia miltiorrhiza Bung)粗制剂对冠心病有效,其醇浸膏经氧化铝层析,再分步重结晶,除分得丹参酮Ⅰ、丹参酮Ⅱ-A、丹参酮Ⅱ-B、隐丹参酮、β-谷甾醇、左旋二氢丹参酮及丹参酸甲酯七种已知化学成分外,还分得一新二萜醌类化合物.经化学和光谱分析测定,确定其结构式为(Ⅱ),定名为次甲丹参醌.邻位二萜醌类化合物在 A 环出现次甲基,植物中是首次被发现.丹参酮Ⅱ-A的水溶性新衍生物——丹参酮Ⅱ-A磺酸钠,经证明其结构式为(Ⅰ).经初步动物耐缺氧试验有效,又经临床验证效果显著,副作用极小,化学上为一新类型治疗冠心病药物.

Dan-Shen, the roots of Salvia miltiorrhvsa Bnnge (Labiatae),is a well-known Chines traditional drug used for treatment of various kinds of diseases including coronary disorders. In recent years, indeed the alcoholic extract of this drug was found to be effective to some kinds of coronary diseases after clinical trials. So the above extract was subjected to separation work, and therefrom several known components such as tanshinone Ⅰ, tanshinone Ⅱ-A, tanshinone Ⅱ-B, cryptotanshinone, β-sitosterol,(-)-dihydrotanshinone, methyltanshinonate were isolated. Besides, a new compound was also obtained and named methylenetanshinqninone. Its structure was elucidated as a diterpene qninone (Ⅱ) by chemical methods and spectral analyses.