化学学报 ›› 1987, Vol. 45 ›› Issue (12): 1170-1174. 上一篇    下一篇

研究论文

黄皮叶化学成分的研究II: 两个新的环酰胺化合物的结构

杨明河;陈延镛;黄量   

  1. 中国医学科学院药物研究所
  • 发布日期:1987-12-15

Studies on the chemical constituents of clausena lansium(lour.) Skeels II: The isolation and structural elucidation of neoclausenamide and cycloclausenamide

YANG MINGHE;CHEN YANYONG;HUANG LIANG   

  • Published:1987-12-15

由黄皮叶的叶中分离到两个具有降谷丙转氨酶活性的内酰胺类化合物-新黄皮胺2和桥环黄皮酰胺3,经光谱分析和化学反应,推定了它们的结构,并讨论了它们相互之间以及黄皮酰胺1之间的关系.3的结构经X射线衍射测定进一步得以肯定.

关键词: 药物, 化学成分, X射线衍射分析, 质子磁共振谱法, 肝炎, 内酰胺, 桥环化合物, 吡咯烷酮 P, 黄皮属, 黄皮酰胺

Two novel lactams, neoclausenamide (I) and cycloclausenamide (II), were identified from the leaves of C. lansium. I and II decreased the level of serum glutamate pyruvate transaminase in mice treated with CCl4 (liver-damaging agent).

Key words: DRUGS, CHEMICAL COMPOSITION, X-RAY DIFFRACTION ANALYSIS, PROTON MAGNETIC RESONANCE SPECTROMETRY, HEPATITIS, LACTAM, BRIDGE COMPOUNDS, PYRROLIDONE P, CLAUSENA, CLAUSENAMIDE

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