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化学学报
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化学学报 ›› 1989, Vol. 47 ›› Issue (11): 1080-1086. 上一篇    下一篇

研究论文

罗汉松科植物中化学成分的研究:I.竹柏中的抗肿瘤成分

徐亚明;方圣鼎   

  1. 中国科学院上海药物研究所
  • 发布日期:1989-11-15

Studies on the chemical constituents of podocarpaceae:I. The cytotoxic constituents from podocarpus naji

XU YAMING;FANG SHENGDING   

  • Published:1989-11-15

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从罗汉松科植物竹柏(Podocarpus nagi(thunb.)Zoll.ct Mor.ex Zoll.)种子中分得七种成分。根据理化性质、波谱数据及化学反应鉴定为竹柏内酯A(1)、1-去氧-2α-羟基竹柏内酯A(3)、竹柏内酯苷A(4)、柳杉酚(5)、β-谷甾醇及蔗糖, 其中4是新化合物, 5是首次从该植物中分得。生物试验表明, 二萜双内酯化合物1-3具有较强的细胞毒作用, 4 无效。对2及3进行了结构改造, 提示了它们的构效关系。

关键词: 内酯, 抗癌药, 构效关系, 二萜, 化学成份, 罗汉松科

Seven compounds are isolated from the seeds of P. nagi (Podocarpaceae) and identified as nagilactone A (I, R1 = b-OH; R2 = R3 = R4 = H), 1-deoxy-2b:3b-epoxynagilactone A (I, R1 = R4 = H; R2, R3 = b-epoxide) (II), 1-deoxy-2a-hydroxy nagilactone A (I, R1 = R3 = R4 = H, R2 = a-OH) (III), nagilactoside A (IV), sugiol, b-sitosterol and sucrose by spectral anal. and chem. methods. I is a new compound Sugiol is reported for the first time to occur in this plant. 14Oassay results show that the first 3 norditerpenoid dilactones had strong cytotoxic activity and IV is inactive. The structures of II and III are modified for studying structure-cytotoxicity relationship.

Key words: LACTONES, ANTICARCINOGEN, STRUCTURE ACTIVITY RELATIONSHIP, DITERPENES, CHEMICAL COMPOSITION, PODOCARPACEAE

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