SIOC English
化学学报
高级检索

化学学报 ›› 1989, Vol. 47 ›› Issue (4): 322-327. 上一篇    下一篇

研究论文

具有生物活性的金属配合物的研究 II: 3,6-二(二甲氨基)-二苯并碘六环稀土乙二胺四乙酸配合物的合成, 性质及抗肿瘤活性

陈淑英;王初华;王欣;侯自杰;李笃;刘力生;宋家玉   

  1. 兰州大学化学系;兰州大学生物系
  • 发布日期:1989-04-15

Study on biologically active coordination compounds of metal ions II: Synthesis, characterization and antitumor activity of rare earth EDTA complexes of 3,6-bis(dimethylamino)-dibenzopyridonium

CHEN SHUYING;WANG CHUHUA;WANG XIN;HOU ZIJIE;LI DU;LIU LISHENG;SONG JIAYU   

  • Published:1989-04-15

PDF

316

被引次数

10

合成了十四种新的3,6-二(二甲氨基)-二苯并碘六环稀土乙二胺四乙酸(EDTA)配合物, 其化学式为[C17H20N2I][RE(EDTA)].xH2O(RE=Ce, x=2; Pr, x=3; Nd-Lu, Y,x=4). 利用热重-差热分析, X射线粉末衍射, 摩尔电导,红外及紫外光谱等对这些配合物进行了表征. 试验表明, 配合物对体外癌(L7712)细胞DNA合成的抑制率较其前体为高.

关键词: 紫外分光光度法, 生物活性, 抗癌药, 红外分光光度法, Ｘ射线衍射分析, 苯 P, 柠檬酸, ＥＤＴＡ Ｐ, 稀土金属络合物, 金属络合物

Q[LnL].xH2O (Q+ = 3,6-bis(dimethylamino)dibenzopyriodonium; H4L = EDTA; Ln = Ce, x = 2; Ln = Pr, x = 3; Ln = Nd-Lu, Y, x = 4) were prepared The complexes were characterized by TG-DTA, x-ray powder diffraction, molar conductance, UV and IR spectra. The inhibiting effect of each complex on incorporation of 3H-TdR into DNA of leukemia (L7712) cells in vitro was observed The results show that they are all more effective than their precursors.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, BIOLOGICAL ACTIVITY, ANTICARCINOGEN, INFRARED SPECTROPHOTOMETRY, X-RAY DIFFRACTION ANALYSIS, BENZENE P, CITRIC ACID, EDTA P, RARE EARTH METAL COMPLEX, METAL COMPLEX

中图分类号: