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化学学报
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化学学报 ›› 1992, Vol. 50 ›› Issue (7): 685-690. 上一篇    下一篇

研究论文

顺铂与F-肌动蛋白的结合方式的LMCT谱研究

王;曾慧慧;王剑;李荣昌   

  1. 北京医科大学药学院
  • 发布日期:1992-07-15

Study on the binding mode of cis-platin to F-actin on the basis of LMCT spectra

WANG XIU;ZENG HUIHUI;WANG JIAN;LI RONGCHANG   

  • Published:1992-07-15

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本文根据顺铂及顺铂与F-肌动蛋白电子光谱中电荷转移谱带研究了顺二氨合铂(II)离子与F-肌动蛋白的结合方式及构型.将所得光谱解极为个别吸收谱带,并与按不同构型、不同配位原子计算结果相比较,结果表明,铂以平面四方形构型主要与两个氨分子、一个硫和一个氨基氮配位.

关键词: 紫外分光光度法, 铂络合物, 顺铂, 顺铂, 配位, F-肌动蛋白, LMCT谱

The binding mode and configuration of cisplatin with F-actin were studied on the basis of charge transfer bands in the electronic spectra of cisplatin and cisplatin-F0-actin. The spectra were resolved to individual absorption bands and were compared with the calculated values corresponding to different binding configurations and ligating atoms. The results indicate a square planar configuration with two ammonia nitrogen, one sulfur and one amino nitrogen binding to platinum.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, PLATINUM COMPLEX, CLSPLATINUM, CLSPLATINUM, COORDINATION

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