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化学学报
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化学学报 ›› 1999, Vol. 57 ›› Issue (2): 155-160. 上一篇    下一篇

研究论文

聚硅氧烷侧链甲基化β-环糊精键合交联手性毛细管柱分离对映体

阮宗琴;李菊白;欧庆瑜;俞惟乐   

  1. 中国科学院兰州化学物理研究所.兰州(730000)
  • 发布日期:1999-02-15

Enantiomer separation on immobilized methylated β -cyclodextrin polysiloxane stationary phase by capillary gas chromatography and electrophoresis

Ruan Zongqin;Li Jubai;Ou Qingyu;Yu Weile   

  1. Lanzhou Inst Chem Phys, CAS.Lanzhou(730000)
  • Published:1999-02-15

PDF

557

被引次数

42

合成了聚硅氧烷侧链的甲基化β-环糊精衍生物手性固定相,成功地进行了固载化,固载化程度高于90%。经测试,柱性能稳定,可在200℃下长期使用。暴露于空气中存放两年,柱效及选择性未见明显改变。对卤代烃及一些醇对映体的直接分离表现出良好的立体选择性,并应用于毛细管电色谱拆分手性化合物。

关键词: 聚硅氧烷P, 甲基化, 环糊精, 毛细管色谱, 气相色谱, 电泳, 固定相, 对映体, 键合, 交联

A methylated β-cyclodextrin polysiloxane was synthesized and a new immobilization method was described. The values of k, α and Rs of an immobilized chiral capillary were almost the same before and after washing with methanol and dichloromethane. The degree of crosslinking was higher than 90%. The maximum permissible temperature was even up to 260℃. After having been exposed to air for two years, column efficiency and enantioselectivity (Rs) were lost ca. 25% and 10% respectively. Racemic halohydrocarbons and alcohols enantiomers can be directly separated. An application of enantiomeric Enantiomeric separation of α -phenylenthanol and fenoprofen was achieved.

Key words: POLYSILOXANE P, METHYLATION, CYCLODEXTRIN, CAPILLARY CHROMATOGRAPHY, GAS CHROMATOGRAPHY, ELECTROPHORESIS, STATIONARY PHASE, ENANTIOMORPH, BONDED, CROSSLINKING

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