化学学报 ›› 2001, Vol. 59 ›› Issue (9): 1490-1494. 上一篇    下一篇

研究论文

芳基脲类衍生物的合成、活性和量子化学计算

王瑾玲;李爱秀;李永红;翟秀红;缪方明   

  1. 天津师范大学晶体化学研究所;中国人民解放军武警部队医学院;南开大学元素 有机化学研究所.天津(300071);中国科学院感光化学研究所.北京(100101)
  • 发布日期:2001-09-15

Syntheses, biological activity and qqantum chemical calculation of aromatic urea derivatives

Wang Jinling;Li Aixiu;Li Yonghong;Di Xiuhong;Miao Fangming   

  1. Nankai Univ, Elementoorgan Chem Lab.Tianjin(300071);Inst Photog Chem, Acad Sinica.Beijing(100101)
  • Published:2001-09-15

芳基脲类化合物是抑制细胞分裂生长的一种抑制剂。本研究报导合成的六个芳基脲类化合物,并利用油菜试法测定了它们抑制油菜胚根生长的生物活性;采用MOPAC程序中的PM3方法进行了量化计算,计算结果较好地解释了新合成化合物结构与生物活性的相关性。

关键词: 脲, 芳基, 生物活性, 量子化学

Aromatic urea compounds usually show cytokinin - inhibition activity. Now six such compounds have been synthesized and their biological rape growing inhibiting activity (IC50) has been determined. The results of quantum chemical calculation, which were performed using PM3 program of MOPAC software are consistant with the measured biological activities and explain the relationship between the structures and biological activities of these compounds.

Key words: UREA, ARYL GROUP, BIOLOGICAL ACTIVITY, QUANTUM CHEMISTRY

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