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化学学报
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化学学报 ›› 2002, Vol. 60 ›› Issue (2): 261-266. 上一篇    下一篇

研究论文

青霉素G钾盐在CTAB/n-C5H11OH/H2O体系中的水解及 其抑制

钱俊红;郭荣;郭霞   

  1. 扬州大学理学院化学化工系.
  • 发布日期:2002-02-15

Inhibition of the hydrolysis of Pen-K in CTAB/n-C5H11OH/H2O systems

Qian Junhong;Guo Rong;Guo Xia   

  1. Yangzhou.
  • Published:2002-02-15

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应用紫外光谱法研究了青霉素G钾盐在十六烷基三甲基溴化铵(CTAB)/n-C5H11OH/H2OO/W微乳液中的水解反应。结果表明，CTAB/n-C5H11OH/H2OO/W微乳液对青毒素G钾盐的水解具有抑制作用，此结果与此O/W微乳液能降低青霉素G钾盐(Pen-K)分子极性基团的电荷密度，减少Pen-K所处微环境的质子浓度有关。

关键词: 抑制, 溴化十六烷基三甲铵, 戊醇, 微乳, 稳定性, 水解, 青霉素G, 紫外分光光度法

The hydrolysis reaction of Pen-K in the CTAB/n-C5H11OH/H2O O/W microemulsion has been studied by UV-vis spectra. The results show that the microemulsion can inhibit the hydrolysis of Pen-K, which indicates the lower charge density of the polar group of Pen-K and the decreased concentration of H^+ in the place where Pen-K locates.

Key words: INHIBITION, PENTANOL, MICROEMUSION, STABILITY, HYDROLYSIS, PENICILLIN G, ULTRAVIOLET SPECTROPHOTOMETRY

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