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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (15): 1527-1531. 上一篇    

研究简报

不同加成数C60精氨酸衍生物的合成及其清除活性氧自由基的性能

胡桢, 黄丽珍, 官文超*   

  1. (华中科技大学化学与化工系 武汉 430074)
  • 投稿日期:2006-10-19 修回日期:2007-01-12 发布日期:2007-08-14
  • 通讯作者: 官文超

Synthesis of Arginine C60 Derivatives with Different Addition Numbers and Their Active Oxygen Radical Scavenging Ability

HU Zhen; HUANG Li-Zhen; GUAN Wen-Chao*   

  1. (Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074)
  • Received:2006-10-19 Revised:2007-01-12 Published:2007-08-14
  • Contact: GUAN Wen-Chao

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通过控制反应配比, 首次合成了三种具有不同加成数目的水溶性C60精氨酸衍生物, C60[HNC(NH)NH(CH2)3CH(NH2)COOH]nHn (n＝2, 6, 8). 采用FT-IR, UV, RF, 1H NMR, 13C NMR, LC-MS, EA, 粒径分析, 透射电镜等手段对其结构进行了表征. 同时采用化学发光法考察了三种具有不同加成数目的C60精氨酸衍生物对活性氧自由基(超氧阴离子O2－.及羟自由基•OH)清除能力, 结果表明, C60精氨酸衍生物对活性氧自由基具有优良的清除能力, 且清除能力与加成基团供电效应、空间位阻及C60精氨酸衍生物在水中的聚集形态等因素密切相关.

关键词: C60精氨酸衍生物, 超氧阴离子, 羟自由基, 化学发光, 自组装

Three water-soluble arginine C60 derivatives with different addition numbers were synthesized for the first time, C60[HNC(NH)NH(CH2)3CH(NH2)COOH]nHn (n＝2, 6, 8). The products were characterized by FT-IR, UV, RF, 1H NMR, 13C NMR, LC-MS, elemental analysis, DLS particle-size analysis and TEM. Meanwhile, the scavenging ability to superoxygen anion radical O2－. and hydroxyl radical •OH was studied by chemiluminescence. It was found that arginine C60 derivatives showed excellent efficiency in eliminating superoxygen anion radical and hy-droxyl radical. The efficiency should be related with many factors, such as donor effect of amino group, steric effect and morphology of the aggregates.

Key words: arginine C60 derivative, superoxygen anion radical, hydroxyl radical, chemiluminescence, self-assembly