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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (1): 138-140. 上一篇    下一篇

研究简报

含叶酸功能端基Pluronic F127的合成及其在水中的形态

邵芳可1，吴唯1，查刘生2，张琰*,1   

  1. (1超细材料制备与应用教育部重点实验室 华东理工大学材料科学与工程学院 上海 200237)
    (2东华大学分析测试中心 上海 200051)
  • 投稿日期:2007-07-12 修回日期:2007-08-17 发布日期:2008-01-14
  • 通讯作者: 张琰

Synthesis of Folic Acid Conjugated Pluronic F127 and Their Morphology in Water

SHAO Fang-Ke1 WU Wei1 ZHA Liu-Sheng2 ZHANG Yan*,1   

  1. (1 Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237)
    (2 Research Center for Analysis and Measurement, Donghua University, Shanghai 200051)
  • Received:2007-07-12 Revised:2007-08-17 Published:2008-01-14
  • Contact: ZHANG Yan

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1191

被引次数

16

通过一系列反应将三嵌段共聚物Pluronic F127的端羟基转变为氨基。利用氨基化F127大单体，最终成功的将生物活性大分子叶酸接到了F127端基上(F127-Folate) 作为靶向配体。利用1H-NMR对嵌段共聚物的结构进行了表征。用透析法制备胶束溶液，利用TEM研究了F127-Folate在水溶液中的自组装形态，结果表明F127-Folate正在水溶液中自组装形成纳米胶束。

关键词: Pluronic F127, 叶酸, 自组装, 胶束

The end hydroxyls of triblock copolymer Pluronic F127 have been modified to amino-groups by a series of reactions. Using the macromonomer aminating F127, the bioactive macromolecular folic acids which are as the targeting ligand have been conjugated to the end group of F127. 1H-NMR and FT-IR were adopted to characterize the structures of copolymers Amphiphilic F127-Folate self-assembled into micelles by dialysis method. The morphologies of the aggregates were investigated by TEM. The results proved that F127-Folate can self-assemble into nanomicelles in water.

Key words: Pluronic F127, Folic acid, Self-assembly, micelles