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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (10): 1265-1268. 上一篇    下一篇

研究论文

二维紫外相关光谱研究复方载药PMMA膜的释放过程

江艳，武培怡*   

  1. (复旦大学高分子科学系聚合物分子工程教育部重点实验室 上海 200433)
  • 投稿日期:2007-06-28 修回日期:2007-10-24 发布日期:2008-05-28
  • 通讯作者: 武培怡

Study on the Release Process of Drug-containing PMMA Film by Two-dimensional UV-Vis Correlation Spectroscopy

JIANG, Yan, WU, Pei-Yi*   

  1. (Key Laboratory of Molecular Engineering of Polymers (Ministry of Education) and Department of Macromolecular Science, Fudan University, Shanghai 200433)
  • Received:2007-06-28 Revised:2007-10-24 Published:2008-05-28
  • Contact: WU, Pei-Yi

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643

被引次数

5 | 2

用紫外-可见光谱(UV-Vis spectroscopy)表征载有布洛芬(ibuprofen)和吡罗昔康(piroxicam)复方药物的聚甲基丙烯酸甲酯(PMMA)膜在磷酸盐缓冲溶液(PBS)中的释放过程, 观察两种药物在时间外扰下的释放情况. 随着时间的推移, 两种药物都保持了持久的释放. 同时, 通过二维紫外相关光谱(two-dimensional UV correlation spectroscopy)来进一步探究两种药物从PMMA膜内释放到缓冲溶液中的先后顺序, 推断出布洛芬与PMMA之间形成了一定的氢键相互作用, 导致释放速度变缓. 复方载药膜的红外光谱证明了这种相互作用的存在, 验证了二维紫外相关光谱在药物缓释领域的潜在应用价值.

关键词: 布洛芬, 吡罗昔康, 聚甲基丙烯酸甲酯, 药物释放, 二维紫外相关光谱

UV-Vis spectroscopy was utilized to monitor the release process of ibuprofen and piroxicam from PMMA film in the phosphate-buffered saline (PBS). Both of the drugs maintained a continuous release process under time perturbation. Furthermore, two-dimensional UV correlation spectroscopy was applied to explore the sequence of the drug release and it was implied that hydrogen-bonding interaction was formed between ibuprofen and poly (methyl methacrylate (PMMA), which was responsible for the lower speed of release. FTIR spectra of drug-containing PMMA film confirmed the existence of the interaction and the potential applications of two-dimensional UV correlation spectroscopy in drug release have been confirmed.

Key words: ibuprofen, piroxicam, PMMA, drug release, two-dimensional UV correlation spectroscopy