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化学学报
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化学学报 ›› 1994, Vol. 52 ›› Issue (5): 468-473. 上一篇    下一篇

研究论文

细胞色素P-450模拟体系的活性中间体-氧配位铬(V)四苯基卟啉 配合物的分离、 表征和氧化反应

舒火明;谷淑珍;金日镇;刘永盛;金钟声   

  1. 中国科学院长春应用化学研究所.长春(130022)
  • 发布日期:1994-05-15

Isolation, characterization and oxidation reaction of active intermediates of cytochrome P-450 model system oxochromium(V) tetraphenylporphyrin complexes

Shu Huoming;Gu Shuzhen;Jin Rizhen;Liu Yongsheng;Jin Zhongsheng   

  1. Changchun Inst Appl Chem., CAS.Changchun(130022)
  • Published:1994-05-15

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氮气保护下二氯甲烷中铬(III)四苯基卟啉衍生物在-40℃与亚碘酰苯反应,分离得氧配位铬(V)四苯基卟啉配合物:O=Cr(V)TPP(Cl)PhI,O=Cr(V)TPP(N~30PhI,O=Cr(V)TPP(p-CH~3O-C~6H~4O)(1/2)PhI。已经元素分析、可见、红外、顺磁、核磁和质谱法结构表征。这些配合物能氧化苯乙烯,环己醇,环己烯和环己烷,可作为细胞色素P-450模拟体系的活性中间体。

关键词: 卟啉, 四苯基卟啉, 铬, 卟啉络合物, 细胞色素P-450, 氧化反应, 二氯甲烷, 氮, 亚碘酰苯, 结构表征

Oxochromium(V) tetraphenylporphyrin complexes, O=Cr(V)TPP(Cl)PhI, O=Cr(V)TPP(N~30PhI, and O=Cr(V)TPP(p-CH~3O- C~6H~4O)(1/2)PhI were isolated from the reaction of Cr(III)TPP(Cl), Cr(III)TPP(N~3)Py or Cr(III)TPP(p-CH~3OC~6H~4O)THF with iodosylbenzene in dichloromethane at -40℃ under nitrogen. They were characterized by elemental analysis, visible, infrared. ESR, NMR and mass spectra. They can oxidize styrene, cyclohexanol, cyclohexene and cyclohexane. They are the active intermediates of cytochrome P-450 model systems.

Key words: PORPHYRIN, CHROMIUM, OXIDATION REACTION, DICHLOROMETHANE, NITROGEN, IODOSOBENZENE, STRUCTURE CHARACTERISTICS

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