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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (2): 157-161. 上一篇    下一篇

研究论文

基于双控荧光开关的NOR和OR分子逻辑门

宗国强a,b 吕功煊*,a

  

  1. (a中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室 兰州 730000)
    (b中国科学院研究生院 北京 100049)

  • 投稿日期:2008-06-04 修回日期:2008-08-04 发布日期:2009-01-28
  • 通讯作者: 吕功煊

NOR and OR Molecular Logic Gates Based on Double-control Fluorescent Switch

Zong, Guoqiang a,b Lü, Gongxuan *,a   

  1. (a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000)
    (b Graduate University of Chinese Academy of Sciences, Beijing 100049)
  • Received:2008-06-04 Revised:2008-08-04 Published:2009-01-28
  • Contact: Lü, Gongxuan

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1500

被引次数

20 | 4

合成了L-精氨酸蒽衍生物1, 考察了碱土及过渡金属离子对主体分子1荧光光谱的影响, 结果发现, 在中性水溶液条件下只有Cu2＋能有效地猝灭其荧光. 另外, 通过OH－/H＋和Cu2＋/乙二胺四乙酸(EDTA)均能对化合物1的荧光强度进行可逆性调控. 在此基础上, 我们以化合物1水溶液作为起始状态, 以OH－和Cu2＋为两化学输入, 构建了一个“或非”(NOR)分子逻辑门; 以1-Cu2＋水溶液体系作为起始状态, 以H＋和EDTA为两化学输入, 构建了一个“或”(OR)分子逻辑门.

关键词: 分子逻辑门, 荧光开关, L-精氨酸, 蒽, Cu2＋

An L-arginine derivative featuring an anthracene unit (1) was synthesized, which could selectively bind Cu2＋in neutral aqueous solutions resulting in fluorescence quenching. Almost no fluorescent changes were observed upon the addition of other metal ions such as Mg2＋, Co2＋, Ba2＋, Ca2＋, Ni2＋, Zn2＋, Cd2＋, Fe3＋and Hg2＋. In addition, the fluorescence intensity of 1 could be reversibly tuned by OH－/H＋or Cu2＋/ethylenediaminetetraacetic acid (EDTA) in the neutral aqueous solutions. Hereby, starting with compound 1 system, a NOR logic gate was fabricated with OH－ and Cu2＋as two chemical inputs. On the other hand, starting with 1-Cu2＋complex system, an OR logic gate was fabricated with H＋and EDTA as two chemical inputs.

Key words: molecular logic gate, fluorescent switch, L-arginine, anthracene, Cu2＋