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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (19): 2205-2209. 上一篇    下一篇

研究论文

功能化纳米粒子作为药物载体的研究

李家诗a   张琰a   陈杰a   王朝华a   郎美东*,a,b   

  1. (a华东理工大学材料科学与工程学院 超细材料制备与应用教育部重点实验室 上海 200237) (b复旦大学聚合物分子工程教育部重点实验室 上海 200433)
  • 投稿日期:2009-05-15 修回日期:2009-05-25 发布日期:2009-06-05
  • 通讯作者: 郎美东 E-mail:mdlang@ecust.edu.cn, mdlang@fudan.edu.cn

Research on Functional Nanoparticles as Drug Carrier

Li, Jiashia      Zhang, Yana       Chen, Jiea         Wang, Chaohuaa      Lang, Meidong*,a,b   

  1. (a Key Laboratory for Ultrafine Materials, Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237) (b Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Fudan University, Shanghai 200433)
  • Received:2009-05-15 Revised:2009-05-25 Published:2009-06-05
  • Contact: Lang Ｍｅｉｄｏｎｇ E-mail:mdlang@ecust.edu.cn, mdlang@fudan.edu.cn

PDF

2476

被引次数

21

将合成的含有羧基侧基官能团的己内酯类聚合物, 用溶剂挥发与超声乳化相结合的方法制备成表面可供修饰的纳米粒子. 利用扫描电镜(SEM)研究了纳米粒子在水溶液中的形态. 使用5-氟脲嘧啶(5-FU)作为模型药物制备了载药纳米粒子, 利用紫外分光光度计法、差示扫描量热法(DSC)、X射线衍射法(XRD)研究了纳米粒子的载药及释放性能. 研究表明, 载药纳米粒子可以控制5-FU的释放速率. 释放时间可持续至96 h 以上, 符合Higuchi 动力学方程.

关键词: ε-己内酯, 纳米粒子, 5-氟脲嘧啶, 药物载体

Carboxylic poly(ε-caprolactone) nanoparticles have been prepared by a emulsification/solvent evaporation method. The morphologies of the nanoparticles were investigated by scanning electron microscope (SEM). 5-Fluorouracil was employed as a model drug for the fabrication of drug loaded nanoparticles. UV spectrometer, differential scanning calorimeter (DSC) and X-ray diffraction (XRD) were adopted to study the entrapment and release behaviour. The results revealed that the release behaviour of 5-FU could be well controlled. The release could last for more than 96 h, and the release behaviour accorded with Higuchi kinetics equation.

Key words: ε-caprolactone, nanoparticle, 5-fluorouracil, drug carrier