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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (22): 2592-2596. 上一篇    下一篇

研究论文

天然蚕丝与丝素蛋白多孔膜的生物降解性研究

黄训亭，邵正中*，陈新   

  1. (复旦大学高分子科学系 教育部聚合物分子工程重点实验室 上海 200433)
  • 投稿日期:2007-04-02 修回日期:2007-06-01 发布日期:2007-11-28
  • 通讯作者: 邵正中

Investigation on the Biodegradation Behavior of Bombyx mori Silk and Porous Regenerated Fibroin Scaffold

HUANG Xun-Ting; SHAO Zheng-Zhong*; CHEN Xin   

  1. (Education Ministry Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433)
  • Received:2007-04-02 Revised:2007-06-01 Published:2007-11-28
  • Contact: SHAO Zheng-Zhong

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840

被引次数

46

较为详细地研究了经不同条件处理的丝素蛋白多孔膜材料和天然蚕丝在蛋白酶作用下的降解性能以及降解前后材料的微观形貌和结构的变化. 结果表明, 丝素蛋白材料中不同结构(构象)的含量是影响其降解速度的一个重要因素. 对于由再生丝素溶液所制备的材料, 调控其中Silk II结构(β-折叠构象)的比例可能是控制丝素蛋白材料降解速度的有效途径.

关键词: 丝素蛋白多孔膜, 天然蚕丝, 生物降解, β-折叠, 蛋白酶

Bombyx mori silk and porous regenerated fibroin scaffold with different treatments were degraded in vitro by a protease. The quantitative, morphologic and structural changes of the materials were evaluated, showing that the conformational content was a very important factor to alter the rate of degradation in the process. Furthermore, for the regenerated fibroin materials, adjusting the content of β-sheet was an efficient method to control the rate of degradation.

Key words: porous regenerated fibroin, Bombyx mori silk, biodegradation, β-sheet, protease