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化学学报
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化学学报 ›› 1998, Vol. 56 ›› Issue (8): 819-826. 上一篇    下一篇

研究论文

四氢叶酸辅酶结构和性能的模拟及取代一碳单元转移反应的研究

陈建新;潘继刚;夏炽中;程津培   

  1. 山西省大同医学专科学校化学室;山西大学化学系;南开大学化学系
  • 发布日期:1998-08-15

Mimicking of structure and properties of tetrahydrofolic coenzyme and study on their substituted one-carbon unit transfer reactions

CHEN JIANXIN;PAN JIGANG;XIA CHIZHONG;CHENG JINPEI   

  • Published:1998-08-15

PDF

848

被引次数

49 | 9

本工作模拟了四氢叶酸辅酶的结构和反应性能, 合成了模型化合物碘化1, 2-二甲基-3-对甲氧苯磺酰基咪唑啉, 研究了模型化合物与单官能团亲核体、双官能团亲核体相作用, 以甲酸、甲醛氧化态转移取代一碳单元[≡C-CH~3, =C(CH~3)CH~2NO~2]的反应, 部分反应生成了咔啉类生物碱衍生物和其它杂环类化合物。

关键词: 咪唑 P, 碘化合物, 有机合成, 仿生, 四氢化物, 一碳化合物, 叶酸, 转移反应, 辅酶, 亲核试剂

Substituted imidazolinium salt, 1, 2-dimethyl-3-(p-methoxybenzenesulfonyl)-imidazolinium iodide, as a tetrahydrofolate model in terms of the ability to transfer a substituted one-carbon unit (ethylidyne, nitromethylethylidene) at the level of formate or formaldehyde, has been synthesized by mimicking the structure and property of tetrahydrofolate coenzyme. The model compound can react with a variety of mono- and bifunctional nucleophiles and lead to some carboline alkaloids and other heterocyclic compounds.

Key words: IMIDAZOLE P, IODINE COMPOUNDS, ORGANIC SYNTHESIS, BIONICS, TETRAHYDRO-COMPOUNDS, C1 COMPOUNDS, FOLIC ACID, TRANSFER REACTIONS, COENZYME, NUCLEOPHILIC REAGENTS

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