本文报道3-甲硫基-5-羟基-1,2,4-三嗪-6-羧酸乙酯(4)及N^2-[5'-(3'-甲硫基-6'-乙氧羰基)-1',2',4'-三嗪基]-3-甲硫基-5-氧代-1,2,4-三嗪-6-羧酸乙酯(8)分子内,甲硫基的氧化及其就地与取代芳胺进行亲核取代反应.3-甲砜基和N^2-[5'-(3'-甲硫基-6'-乙氧羰基)-1',2',4'-三嗪基]作为离去基,其离去能力相近.
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蔡孟深,程铁明,贾琦. 1,2,4-三嗪类化合物的研究 VIII: 3-甲硫基-5-羟基-1,2,4-三嗪-6-羧酸乙酯和N^2-[5'-(3'-甲硫基-6'-乙氧羰基)-1',2',4'-三嗪基]-3-甲硫基-5-氧代-1,2,4-三嗪-6-羧酸乙酯的氧化及其取代反应[J]. 化学学报, 1987, 45(2): 185-190.
CAI MENGSHEN;CHENG TIEMING;JIA QI. Chemistry of 1,2,4-triazines VIII: The oxidation of ethyl 3-methylthio-5-hydroxy-1,2,4-triazine-6-carboxylate and ethyl N^2-[5'(3)-methylthio-6'-ethoxycarbonyl)-1',2',4',-triazinyl]-3-methylthio-5- oxo-1,2,4-triazine-6-carboxylate and the substitution rea[J]. Acta Chimica Sinica, 1987, 45(2): 185-190.
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