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化学学报
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化学学报 ›› 2006, Vol. 64 ›› Issue (19): 1988-1992. 上一篇    下一篇

研究论文

含有磺胺的多金属氧酸盐的合成及抑制前列腺癌细胞PC-3M作用的研究

刘霞1, 赵军2, 冯长根*,2   

  1. (1中国农业大学理学院 北京 100094)
    (1北京理工大学新医药开发研究中心 北京 100081)
  • 投稿日期:2005-12-08 修回日期:2006-03-15 发布日期:2006-10-14
  • 通讯作者: 冯长根

Studies on the Synthesis of Polyoxometalates Containing Sulfanilamide and Their Inhibition to Prostate Cancer Cell PC-3M

LIU Xia1; ZHAO Jun2; FENG Chang-Gen*,2   

  1. (1 College of Science, China Agricultural University, Beijing 100094)
    (2 Research and Development Center of New Medication, Beijing Institute of Technology, Beijing 100081)
  • Received:2005-12-08 Revised:2006-03-15 Published:2006-10-14
  • Contact: FENG Chang-Gen

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被引次数

66 | 7

合成了(C6H9N2O2S)5HP2Mo18O62•15H2O (SPOM-1)和(C6H9N2O2S)H8P2Mo15V3O62•8H2O (SPOM-2)两种新的含有磺胺的多金属氧酸盐, 通过元素分析、IR光谱对其结构进行了表征. 在人雄激素非依赖性前列腺癌细胞系PC-3M内, 对合成的多金属氧酸盐进行了抗肿瘤活性的研究. 研究发现, SPOM-1, SPOM-2在体外能明显抑制前列腺癌PC-3M细胞, 并呈一定的量效关系, EC50分别为38, 11 g•mL－1; 治疗指数(TI)分别为12.07, 26.82; SPOM-2的抗前列腺癌PC-3M细胞活性大于SPOM-1.

关键词: 磺胺, 多金属氧酸盐, 抑制, 前列腺癌

Two new polyoxometalates namely (C6H9N2O2S)5HP2Mo18O62•15H2O (SPOM-1) and (C6H9N2O2S)• H8P2Mo15V3O62•8H2O (SPOM-2) containing sulfanilamide were synthesized and structurally characterized by elementary analysis and IR spectra. The antitumor activities of these compounds had been investigated in human androgen independent prostate cancer cell PC-3M. SPOM-1 and SPOM-2 were shown to inhibit prostate cancer cell PC-3M significantly, and there was a certain dose-effect relationship. EC50 for the two samples was 38 and 11 μg•mL－1, respectively, and therapeusis index (TI) was 12.07 and 26.82, respectively. It was concluded from the test that the activity of SPOM-2 inhibiting prostate cancer cell PC-3M was superior to that of SPOM-1.

Key words: sulfanilamide, polyoxometalate, inhibition, prostate cancer