化学学报 ›› 1983, Vol. 41 ›› Issue (9): 829-833. 上一篇    下一篇

研究论文

若干17β-乙酰氧基甾族化合物用节杆菌芳构化时的水解

周维善;胡波;倪元   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1983-09-15

Microbial hydrolysis of some 17β-acetoxy steroids during aromatization with arthrobacter simplex

ZHOU WEISHAN;HU BO;NI YUAN   

  • Published:1983-09-15

关键词: 水解, 甾族化合物, 乙酰氧基, 节杆菌属, 微生物转化, 芳构化

During aromatization with Arthrobacter simplex 17β-acetoxy steroidal compounds 3-12 afforded 17β-hydroxy, 17-keto or intact 17β-acetoxy ring A aromatic compounds 13-18. The 17-ketones 14 and 17 were probably formed through the oxidation of the corresponding 17β-ol formed during fermentation with this microorganism. Hydrolysis of 17β-acetoxy group is depedent upon other substitutent present in the substrates.

Key words: HYDROLYSIS, STEROIDS, ACETOXY GROUP, ARTHROBACTER, MICROBIAL TRANSFORMATION, AROMATIZATION

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