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化学学报
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化学学报 ›› 2011, Vol. 69 ›› Issue (13): 1503-1508. 上一篇    下一篇

研究论文

泊洛沙姆F127和丹皮酚对GMO液晶相变的影响

李超1, 高缘2, 张建军*,1, 朱家壁*,1, 吴莲花2   

  1. (1中国药科大学药剂教研室 南京 210009)
    (2中国药科大学中药制剂教研室 南京 210009)
  • 投稿日期:2011-01-04 修回日期:2011-02-12 发布日期:2011-03-25
  • 通讯作者: 张建军 E-mail:amicute@163.com
  • 基金资助:

    国家“重大新药创制”科技重大专项新制剂与新释药系统技术平台资助项目

Effect of Poloxamer F127 and Paeonol on GMO-Based Liquid Crystal Transformation

Li Chao1; Gao Yuan2; Zhang Jianjun*,1; Zhu Jiabi*,1; Wu Lianhua2   

  1. (1 Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009)
    (2 Department of Chinese Medicine Pharmaceutics, China Pharmaceutical University, Nanjing 210009)
  • Received:2011-01-04 Revised:2011-02-12 Published:2011-03-25

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1412

被引次数

8

对GMO/H2O, GMO/F-127/H2O和GMO/paeonol/H2O三种体系的液晶特性进行了考察, 结合粘度及偏光纹理绘制相图, 运用“drying”方法的原理鉴别了反相胶束和立方相液晶, 并采用临界堆积参数p值理论探讨水溶性和脂溶性物质引起液晶相变的机理. 结果表明水溶性泊洛沙姆F127可使层状液晶区域变宽, 立方相液晶区域变窄|脂溶性丹皮酚可使层状液晶和立方相液晶区域变窄, 反相六角相液晶变宽. 本研究通过对单油酸甘油酯(GMO)液晶特征的研究, 为其作为载体的应用提供了理论基础.

关键词: 液晶, 相变, 泊洛沙姆, 丹皮酚, 临界堆积参数

The liquid crystalline characteristics of GMO/H2O, GMO/F-127/H2O and GMO/paeonol/H2O systems were studied. Phase diagrams were constructed based on viscosity observation and polarized light textures of the systems. The principle of “drying” method was applied to distinguish reversed micelle and cubic liquid crystal. The dimensionless packing parameter (p＝V/al) was used to investigate the mechanism why and how a hydrophilic additive or a lipophilic additive could induce the transformation of GMO-based liquid crystal. It was demonstrated that the hydrophilic F127 could narrow the cubic phase and broaden the lamellar phase, while lipophilic paeonol could narrow both cubic and lamellar phase and make them convert into reversed hexagonal phase. The GMO-based liquid crystals and its transformation that provided the characteristics structure of glyceryl monooleate (GMO) were studied so as to provide rationale for its application as the carrier in drug delivery.

Key words: liquid crystal, phase transformation, poloxamer, paeonol, dimensionless packing parameter