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化学学报
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化学学报 ›› 1976, Vol. 34 ›› Issue (1): 31-37. 上一篇    下一篇

论文

肿瘤的化学治疗——与放线菌素有关的化合物1,9-二[N-烷基-甲氨酰(或烷氧羰基)]-4,6-二取代基-2-氨基吩噁嗪酮-(3)的合成

李述文1, 朱珍燕2   

  1. 1. 上海药物研究所;
    2. 北京医学院药学系
  • 投稿日期:1975-08-01 发布日期:2013-06-03

TUMOUR CHEMOTHERAPY——SYNTHESIS OF COMPOUNDS RELATED TO ACTINOMYCINS 1, 9-DI-[N-ALKYLCARBAMYL(OR ALKOXY-CARBONYL)]-4, 6-DISUBSTITUTED-2-AMINO-PHENOXAZONE-(3)

LI SHU-WEN1, CHU JEN-YEN2   

  1. Shanghai Institute of Materia Medica
  • Received:1975-08-01 Published:2013-06-03

PDF

423

被引次数

1

本文叙述二十个与放线菌素有关的化合物1,9-二(N-烷基-甲氨酰(或烷氧羰基)]-4,6-二取代基(H或CH3)-2-氨基吩噁嗪酮-(3)的合成.企图从增加化合物的脂溶性,以观察其与抗肿瘤作用的关系.经初步生物试验发现,化合物Ⅲa,Ⅳa,Ⅴa和Ⅵa在浓度100微克/毫升时,对体外培养的Hela细胞有一定的抑制作用,但对小白鼠肉瘤180及肉瘤37和抗菌试验均无明显作用.

In an attempt to modify the solubility behaviour of aotinomyains so as to improve the usefulness of this antibiotic in the treatment of tumours,the authors prepared a series of 1,9-di [N-alkyl(medium and long chain) carbamyl(or alkogy-carbonyl)]-4,6-disubstituted-2-amino-phenogazone-(3)(Ⅲ,Ⅳ,Ⅴ and Ⅵ),in which the hydrophobic groups were introduoed in place of the polypeptide moiety of the molecules of actinomycins.