近红外二区荧光探针在活体多重成像中的研究进展

doi:10.6023/A24070218

化学学报 ›› 2024, Vol. 82 ›› Issue (10): 1069-1085.DOI: 10.6023/A24070218 上一篇下一篇

综述

近红外二区荧光探针在活体多重成像中的研究进展

蒋励, 陈子晗, 凡勇^*()

复旦大学化学系聚合物工程国家重点实验室上海 200438

投稿日期:2024-07-16 发布日期:2024-09-13

作者简介:

蒋励, 男, 汉族, 2001年出生于浙江温州, 2023年6月毕业于四川大学化学学院, 2023年9月进入复旦大学化学系攻读博士学位, 研究方向为近红外二区多重成像.

陈子晗, 本科毕业于华东师范大学化学与分子工程学院, 2019年9月进入复旦大学化学系攻读博士研究生. 目前已在Angew. Chem. Int. Ed.、TrAC Trend Anal. Chem.等期刊上发表第一作者论文4篇, 研究方向为稀土纳米材料的合成与近红外二区成像、疾病相关标志物的荧光检测方法与体外多靶标诊断.

凡勇, 复旦大学化学系教授, 博士生导师, 国家优秀青年基金获得者. 2009年获得西安交通大学理学学士学位, 2015年获得清华大学物理系理学博士学位, 2015~2018年复旦大学化学系博士后, 2019年1月加入复旦大学化学系, 主要研究领域包括功能性近红外荧光纳米材料、荧光介观材料的设计与合成及其在医学成像、疾病诊断和治疗中的应用.

基金资助:
国家自然科学基金优秀青年基金(22222403); 国家自然科学基金国际(地区)合作与交流项目(22161160320); 国家自然科学基金面上项目(32171377); 上海市基础研究领域重大项目(22JC1400400)

Research Progress on Fluorescent Probes in the Second Near-Infrared Window for In Vivo Multiplexed Imaging

Li Jiang, Zihan Chen, Yong Fan()

State Key Laboratory of Molecular Engineering of Polymers, Department of Chemistry, Fudan University, Shanghai 200433

Received:2024-07-16 Published:2024-09-13
Contact: *E-mail: fan_yong@fudan.edu.cn
Supported by:
National Science Fund for Excellent Young Scholars(22222403); International (Regional) Cooperation and Exchange (ICE) Projects of the National Natural Science Foundation of China (NSFC)(22161160320); National Natural Science Foundation of China(32171377); Key Basic Research Program of Science and Technology Commission of Shanghai Municipality(22JC1400400)

文章分享

摘要/Abstract

近红外二区(NIR-II, 1000~1700 nm)荧光成像技术, 因生物组织对其低的吸收和散射, 以及接近零的自体荧光背景噪声, 使得其在生物体内具备深的穿透能力以及高的分辨率和信噪比, 目前已经成为活体内研究的一种新型的技术手段, 尤其适用于活体组织内的多重成像. 本综述首先回顾了NIR-II荧光探针的设计与合成, 涵盖稀土基纳米颗粒、量子点及有机荧光分子等, 并探讨了多重成像技术对方法和设备的需求与成像技术进展, 最后分析了它们在血管/肿瘤/淋巴、多器官以及细胞层面的多重成像应用. 同时, 也展望了该新型成像模式在未来发展中的方向以及最终走向临床应用所面临的挑战.

关键词: 近红外二区, 荧光探针, 多重成像, 活体分析

Due to the low absorption and scattering effects as well as near-zero autofluorescence background noise, imaging in the second near-infrared window (NIR-II, 1000~1700 nm) shows deep penetration with a high resolution and signal-to-noise ratio in biological tissues, which makes it one of the promising optical imaging techniques for in vivo study, especially suitable for multiplexed and real-time analysis. In this review, we first discuss the properties and advantages of NIR-II bioimaging, including a division and evaluation of the different NIR-II sub-windows, which analyze the specific properties of each sub-window for various biological applications. Then, we outline the recent design and synthesis of NIR-II fluorescent probes, including rare earth-based nanoparticles, quantum dots, organic molecules, and other NIR-II materials. These materials are critically evaluated for their potential to enhance imaging performance and their specific suitability for different multiplexed imaging scenarios. This review also introduces the equipment used for NIR-II wide-field and microscopic imaging. Additionally, it introduces the two NIR-II multiplexed in vivo imaging modalities: emission multiplexing and excitation multiplexing. Subsequently, multiplexed imaging applications for blood vessel, tumor, lymphatic system, multi-organ, and cellular levels are highlighted, showcasing how these advances allow for more detailed, simultaneous observations of complex biological processes across different scales of biological organization. Such applications demonstrate the growing potential of NIR-II multiplexed imaging in providing new insights into disease mechanisms and in aiding the development of more targeted therapeutic strategies. Finally, dynamic multiplexed NIR-II imaging offers significant potential for advancing biomedical research and clinical applications by enabling deep-tissue, high-resolution imaging of multiple biological targets. However, current limitations in the availability and applicability of probes necessitate further development of efficient, long-wavelength probes and addressing challenges related to biological safety and clinical translation. As the technology advances, NIR-II imaging is expected to achieve breakthroughs in real-time dynamic multiplexed imaging and functional biosensing, paving the way for its integration into clinical applications.

Key words: second near-infrared window, fluorescent probes, multiplexed imaging, in vivo analysis

引用此文

蒋励, 陈子晗, 凡勇. 近红外二区荧光探针在活体多重成像中的研究进展[J]. 化学学报, 2024, 82(10): 1069-1085.

Li Jiang, Zihan Chen, Yong Fan. Research Progress on Fluorescent Probes in the Second Near-Infrared Window for In Vivo Multiplexed Imaging[J]. Acta Chimica Sinica, 2024, 82(10): 1069-1085.

导出引用 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

分享此文

图/表 7

图1. 生物组织中的光衰减: (a) 光与组织的相互作用[35]; (b) 在808 nm激光激发下不同组织的自体荧光光谱[35]; (c) 不同生物组织和脱脂肪乳剂组织在400~2000 nm波段的散射系数(μs'); (d) 水在400~2300 nm范围内的吸收光谱; (e) 不同NIR-II波段的小鼠血管成像结果[12]; (f) 通过蒙特卡洛(Monte Carlo)方法模拟的近红外生物组织成像结果[36]

Figure 1. Light attenuation in biological tissues: (a) light-tissue interactions[35]; (b) autofluorescence spectra of different tissues at 808 nm laser excitation[35]; (c) reduced scattering coefficients (μs') of different biological tissues and intralipid tissue from 400 to 2000 nm; (d) absorption spectra of water from 400 nm to 2300 nm; (e) imaging results of mouse vasculature across different NIR-II regions[12]; (f) the simulation results of NIR biological tissue imaging via the Monte Carlo method[36]

图2. NIR-II荧光探针: (a)稀土离子Sm3+、Yb3+、Nd3+、Ho3+、Tm3+、Pr3+、Dy3+和Er3+在晶体中的近红外发射光谱及能级[72]; (b)金属-大环络合物[66]; (c)不同尺寸的Ag2Te量子点发射光谱[80]; (d)通过限制分子内运动实现聚集诱导发光(AIE)的机理[81]; (e)近红外二区分子荧光染料聚亚甲基、D-A-D染料和硅-罗吲哚嗪染料的示例结构[64,82???-86]; (f)通过π-π堆叠修饰的SWCNTs[87]; (g) Au25纳米团簇[88]; (h) CISe纳米管的受限自组装[89]

Figure 2. NIR-II fluorescence probes: (a) NIR luminescence spectra and the energy levels of various lanthanide ions including Sm3+, Yb3+, Nd3+, Ho3+, Tm3+, Pr3+, Dy3+, and Er3+ in crystals hosts[72]; (b) metal-macrocycles complexes[66]; (c) emission spectra of Ag2Te quantum dots of different sizes[80]; (d) the mechanism of AIE through restriction of intramolecular motion at a morphological level[81]; (e) example structures of the NIR-II molecular fluorophores polymethine, D-A-D dyes and Silicon-RosIndolizine[64,82???-86]; (f) SWCNTs modified by π-π stacking[87]; (g) Au25 nanoclusters[88]; (h) self-limited assembly of CISe nanotubes[89]

图3. NIR-II成像设备: (a)宽场第二近红外(NIR-II)荧光成像[59]; (b)寿命成像[30]; (c)光栅扫描共聚焦NIR-II荧光成像[111]; (d)定制化的NIR-II双通道显微系统[118]; (e) NIR-II光片显微镜[111]

Figure 3. NIR-II imaging equipment: (a) wide-field NIR-II fluorescence imaging[59]; (b) lifetime-resolved imaging[30]; (c) raster-scan confocal NIR-II fluorescence imaging[111]; (d) the custom-built NIR-II dual-channel microscopy system[118]; (e) NIR-II light-sheet microscopy[111]

图4. 近红外二区活体多重成像的模式: (a)发射波长调控的多重成像; (b)激发波长调控的多重成像

Figure 4. NIR-II multiplexed in vivo imaging modalities: (a) emission multiplexing; (b) excitation multiplexing

图5. 血管/肿瘤/淋巴多重成像: (a)大脑肿瘤、动脉和静脉的NIR-II成像[98]; (b) CT-26肿瘤小鼠在静脉注射ErNPs-aPDL1和PbS QDs-aCD8后24 h的NIR-IIb双重成像[112]; (c)使用NIR-I-BPs和NIR-II-BPs的淋巴系统双通道生物发光成像[123]; (d)多重寿命成像用于乳腺癌的精确诊疗[30]; (e) NIR-II成像指导胶质瘤手术; (f) NIR-II成像指导宫颈癌手术[128]

Figure 5. Multiplexed imaging of vascular, tumor, and lymph systems: (a) NIR-II imaging of a brain tumor, arteries and veins[98]; (b) dual-channel NIR-IIb imaging of a mouse bearing a CT-26 tumor at 24 h post intravenous injection of ErNPs-aPDL1 and PbS QDs-aCD8[112]; (c) dual-channel bioluminescence imaging of lymph system with NIR-I-BPs and NIR-II-BPs[123]; (d) utilizing multiplexed lifetime imaging for precise diagnosis and treatment of breast cancer[30]; (e) utilization of NIR-II fluorescence imaging during glioma surgery; (f) utilization of NIR-II fluorescence imaging during cervical cancer surgery[128]

图6. 器官多重成像: (a)体内外器官寿命多重成像[124]; (b)活体小鼠多器官双通道长余辉成像[122]; (c)血管和小肠的动态多重成像[70]

Figure 6. Multiplexed imaging of organs: (a) multiplexed lifetime imaging of organs in vivo and in vitro[124]; (b) dual-channel in vivo PL imaging of organs in a living mouse[122]; (c) dynamic multiplexed imaging of blood vessels and small intestine[70]

图7. 细胞多重成像: (a)小鼠通过心内注射标记有CT1530的人类骨肉瘤143B细胞和Cy7.5的磷脂胶束, 随后进行活体显微成像[66]; (b)标记有CT1530的143B细胞和小鼠脑部血管图像及其叠加图[66]; (c)体外肿瘤的三维光片显微成像[13]; (d)血管内中性粒细胞的实时成像[12]

Figure 7. Multiplexed imaging of cell: (a) mice received CT1530-labelled cells and Cy7.5-labelled phospholipid micelles through intracardiac injection, followed by through-skull intravital microscopy[66] ; (b) representative images of the CT1530-labelled 143B cells and the Cy7.5-labelled vessels with their overlay image[66]; (c) three-dimensional volumetric NIR-II SIM images of tumor tissue ex vivo[13]; (d) real-time imaging of neutrophils within blood vessels[12]

参考文献 130

[1]	Fan, Y.; Wang, S.; Zhang, F. Angew. Chem. Int. Ed. 2019, 58 13208.
[2]	Shimomura, O.; Johnson, F. H.; Saiga, Y. J. Cell. Physiol. 1962, 59 223.
[3]	Hell, S. W.; Wichmann, J. Opt. Lett. 1994, 19 780. doi: 10.1364/ol.19.000780 pmid: 19844443
[4]	Reinhardt, S. C. M.; Masullo, L. A.; Baudrexel, I.; Steen, P. R.; Kowalewski, R.; Eklund, A. S.; Strauss, S.; Unterauer, E. M.; Schlichthaerle, T.; Strauss, M. T.; Klein, C.; Jungmann, R. Nature 2023, 617 711.
[5]	Irkle, A.; Vesey, A. T.; Lewis, D. Y.; Skepper, J. N.; Bird, J. L. E.; Dweck, M. R.; Joshi, F. R.; Gallagher, F. A.; Warburton, E. A.; Bennett, M. R.; Brindle, K. M.; Newby, D. E.; Rudd, J. H.; Davenport, A. P. Nat. Commun. 2015, 6 7495.
[6]	Helms, G.; Dathe, H.; Kallenberg, K.; Dechent, P. Magn. Reson. Med. 2008, 60 1396.
[7]	Clough, T. J.; Jiang, L.; Wong, K.-L.; Long, N. J. Nat. Commun. 2019, 10 1420.
[8]	Jathoul, A. P.; Laufer, J.; Ogunlade, O.; Treeby, B.; Cox, B.; Zhang, E.; Johnson, P.; Pizzey, A. R.; Philip, B.; Marafioti, T.; Lythgoe, M. F.; Pedley, R. B.; Pule, M. A.; Beard, P. Nat. Photonics 2015, 9 239.
[9]	Pu, K.; Shuhendler, A. J.; Jokerst, J. V.; Mei, J.; Gambhir, S. S.; Bao, Z.; Rao, J. Nat. Nanotechnol. 2014, 9 233.
[10]	Pratt, E. C.; Skubal, M.; Mc Larney, B.; Causa-Andrieu, P.; Das, S.; Sawan, P.; Araji, A.; Riedl, C.; Vyas, K.; Tuch, D.; Grimm, J. Nat. Biomed. Eng. 2022, 6 559.
[11]	Hu, L.; Dong, C.; Wang, Z.; He, S.; Yang, Y.; Zi, M.; Li, H.; Zhang, Y.; Chen, C.; Zheng, R.; Jia, S.; Liu, J.; Zhang, X.; He, Y. Aging Cell 2023, 22, e13896.
[12]	Yang, Y.; Chen, Y.; Pei, P.; Fan, Y.; Wang, S.; Zhang, H.; Zhao, D.; Qian, B.-Z.; Zhang, F. Nat. Nanotechnol. 2023, 18 1195.
[13]	Ren, F.; Wang, F.; Baghdasaryan, A.; Li, Y.; Liu, H.; Hsu, R.; Wang, C.; Li, J.; Zhong, Y.; Salazar, F.; Xu, C.; Jiang, Y.; Ma, Z.; Zhu, G.; Zhao, X.; Wong, K. K.; Willis, R.; Christopher Garcia, K.; Wu, A.; Mellins, E.; Dai, H. Nat. Biomed. Eng. 2023, 726.
[14]	Li, C.; Wang, Q. ACS Nano 2018, 12 9654.
[15]	Ntziachristos, V. Nat. Methods 2010, 7 603. doi: 10.1038/nmeth.1483 pmid: 20676081
[16]	Voelker, R. JAMA 2022, 327 27.
[17]	Zhang, P.; Wu, Q.; Yang, J.; Hou, M.; Zheng, B.; Xu, J.; Chai, Y.; Xiong, L.; Zhang, C. Acta Biomater. 2022, 146 450.
[18]	Ding, S.; Lu, L.; Fan, Y.; Zhang, F. J. Rare Earths 2020, 38 451.
[19]	Frangioni, J. V. Curr. Opin. Chem. Biol. 2003, 7 626. doi: 10.1016/j.cbpa.2003.08.007 pmid: 14580568
[20]	Lai, Y.; Dang, Y.; Sun, Q.; Pan, J.; Yu, H.; Zhang, W.; Xu, Z. Chem. Sci. 2022, 13 12511. doi: 10.1039/d2sc05242c pmid: 36349272
[21]	Feng, Z.; Bai, S.; Qi, J.; Sun, C.; Zhang, Y.; Yu, X.; Ni, H.; Wu, D.; Fan, X.; Xue, D.; Liu, S.; Chen, M.; Gong, J.; Wei, P.; He, M.; Lam, J. W. Y.; Li, X.; Tang, B. Z.; Gao, L.; Qian, J. Adv. Mater. 2021, 33 2008123.
[22]	Yu, W. Q.; Liu, R.; Zhou, Y.; Gao, H. L. ACS Cent. Sci. 2020, 6 100.
[23]	Zhang, Z.; Du, Y.; Shi, X.; Wang, K.; Qu, Q.; Liang, Q.; Ma, X.; He, K.; Chi, C.; Tang, J.; Liu, B.; Ji, J.; Wang, J.; Dong, J.; Hu, Z.; Tian, J. Nat. Rev. Clin. Oncol. 2024, 21 449. doi: 10.1038/s41571-024-00892-0 pmid: 38693335
[24]	Peloso, A.; Franchi, E.; Canepa, M. C.; Barbieri, L.; Briani, L.; Ferrario, J.; Bianco, C.; Quaretti, P.; Brugnatelli, S.; Dionigi, P.; Maestri, M. HPB 2013, 15 928.
[25]	Cousins, A.; Thompson, S. K.; Wedding, A. B.; Thierry, B. Biotechnol. Adv. 2014, 32 269. doi: 10.1016/j.biotechadv.2013.10.011 pmid: 24189095
[26]	Hong, G.; Antaris, A. L.; Dai, H. Nat. Biomed. Eng. 2017, 1 0010.
[27]	Lifante, J.; Shen, Y.; Ximendes, E.; Martín Rodríguez, E.; Ortgies, D. H. J. Appl. Phys. 2020, 128 171101.
[28]	Huang, S.; Heikal, A. A.; Webb, W. W. Biophys. J. 2002, 82 2811.
[29]	Becker, W. J. Microsc. 2012, 247 119.
[30]	Fan, Y.; Wang, P.; Lu, Y.; Wang, R.; Zhou, L.; Zheng, X.; Li, X.; Piper, J. A.; Zhang, F. Nat. Nanotechnol. 2018, 13 941.
[31]	Jacques, S. L. Phys. Med. Biol. 2013, 58, R37.
[32]	Horton, N. G.; Wang, K.; Kobat, D.; Clark, C. G.; Wise, F. W.; Schaffer, C. B.; Xu, C. Nat. Photonics 2013, 7 205.
[33]	Wang, F.; Ren, F.; Ma, Z.; Qu, L.; Gourgues, R.; Xu, C.; Baghdasaryan, A.; Li, J.; Zadeh, I. E.; Los, J. W. N.; Fognini, A.; Qin-Dregely, J.; Dai, H. Nat. Nanotechnol. 2022, 17 653.
[34]	Pansare, V. J.; Hejazi, S.; Faenza, W. J.; Prud’homme, R. K. Chem. Mater. 2012, 24 812. pmid: 22919122
[35]	Chen, Y.; Wang, S.; Zhang, F. Nat. Rev. Bioeng. 2023, 1 60.
[36]	Feng, Z.; Tang, T.; Wu, T.; Yu, X.; Zhang, Y.; Wang, M.; Zheng, J.; Ying, Y.; Chen, S.; Zhou, J.; Fan, X.; Zhang, D.; Li, S.; Zhang, M.; Qian, J. Light Sci. Appl. 2021, 10 197.
[37]	Carr, J. A.; Aellen, M.; Franke, D.; So, P. T. C.; Bruns, O. T.; Bawendi, M. G. Proc. Natl. Acad. Sci. 2018, 115 9080.
[38]	Feng, Z.; Li, Y.; Chen, S.; Li, J.; Wu, T.; Ying, Y.; Zheng, J.; Zhang, Y.; Zhang, J.; Fan, X.; Yu, X.; Zhang, D.; Tang, B. Z.; Qian, J. Nat. Commun. 2023, 14 5017. doi: 10.1038/s41467-023-40728-6 pmid: 37596326
[39]	Koman, V. B.; Bakh, N. A.; Jin, X.; Nguyen, F. T.; Son, M.; Kozawa, D.; Lee, M. A.; Bisker, G.; Dong, J.; Strano, M. S. Nat. Nanotechnol. 2022, 17 643.
[40]	Ming, J.; Chen, Y.; Miao, H.; Fan, Y.; Wang, S.; Chen, Z.; Guo, Z.; Guo, Z.; Qi, L.; Wang, X.; Yun, B.; Pei, P.; He, H.; Zhang, H.; Tang, Y.; Zhao, D.; Wong, G. K.-L.; Bünzli, J.-C. G.; Zhang, F. Nat. Photonics 2024, DOI: 10.1038/s41566-024-01517-9.
[41]	Mei, M.; Wu, B.; Wang, S.; Zhang, F. Curr. Opin. Chem. Biol. 2024, 80 102469.
[42]	Wang, F. F.; Ma, Z. R.; Zhong, Y. T.; Salazar, F.; Xu, C.; Ren, F. Q.; Qu, L. Q.; Wu, A. M.; Dai, H. J. Proc. Natl. Acad. Sci. 2021, 118, e2023888118.
[43]	Ma, Z. R.; Wang, F. F.; Zhong, Y. T.; Salazar, F.; Li, J. C.; Zhang, M. X.; Ren, F. Q.; Wu, A. N. M.; Dai, H. J. Angew. Chem. Int. Ed. 2020, 59 20552.
[44]	Zhu, X.; Zhang, H.; Zhang, F. Acc. Mater. Res. 2023, 4 536.
[45]	Zhao, M.; Sik, A.; Zhang, H.; Zhang, F. Adv. Opt. Mater. 2023, 11 2202039.
[46]	Ma, Z. R.; Wan, H.; Wang, W. Z.; Zhang, X. D.; Uno, T.; Yang, Q. L.; Yue, J. Y.; Gao, H. P.; Zhong, Y. T.; Tian, Y.; Sun, Q. C.; Liang, Y. Y.; Dai, H. J. Nano Res. 2019, 12 273.
[47]	Zhu, X.; Wang, X.; Zhang, H.; Zhang, F. Angew. Chem. Int. Ed. 2022, 61, e202209378.
[48]	Wan, H.; Ma, H. L.; Zhu, S. J.; Wang, F. F.; Tian, Y.; Ma, R.; Yang, Q. L.; Hu, Z. B.; Zhu, T.; Wang, W. Z.; Ma, Z. R.; Zhang, M. X.; Zhong, Y. T.; Sun, H. T.; Liang, Y. Y.; Dai, H. J. Adv. Funct. Mater. 2018, 28 1804956.
[49]	Zhong, Y. T.; Ma, Z. R.; Zhu, S. J.; Yue, J. Y.; Zhang, M. X.; Antaris, A. L.; Yuan, J.; Cui, R.; Wan, H.; Zhou, Y.; Wang, W. Z.; Huang, N. F.; Luo, J.; Hu, Z. Y.; Dai, H. J. Nat. Commun. 2017, 8 737.
[50]	Antaris, A. L.; Chen, H.; Cheng, K.; Sun, Y.; Hong, G. S.; Qu, C. R.; Diao, S.; Deng, Z. X.; Hu, X. M.; Zhang, B.; Zhang, X. D.; Yaghi, O. K.; Alamparambil, Z. R.; Hong, X. C.; Cheng, Z.; Dai, H. J. Nat. Mater. 2016, 15 235.
[51]	Diao, S.; Blackburn, J. L.; Hong, G. S.; Antaris, A. L.; Chang, J. L.; Wu, J. Z.; Zhang, B.; Cheng, K.; Kuo, C. J.; Dai, H. J. Angew. Chem. Int. Ed. 2015, 54 14758.
[52]	Hong, G. S.; Robinson, J. T.; Zhang, Y. J.; Diao, S.; Antaris, A. L.; Wang, Q. B.; Dai, H. J. Angew. Chem. Int. Ed. 2012, 51 9818.
[53]	Hong, G. S.; Lee, J. C.; Robinson, J. T.; Raaz, U.; Xie, L. M.; Huang, N. F.; Cooke, J. P.; Dai, H. J. Nat. Med. 2012, 18 1841.
[54]	Welsher, K.; Sherlock, S. P.; Dai, H. J. Proc. Natl. Acad. Sci. 2011, 108 8943.
[55]	Liu, Z.; Tabakman, S.; Welsher, K.; Dai, H. J. Nano Res. 2009, 2 85.
[56]	Xiong, L.; Fan, Y.; Zhang, F. Acta Chim. Sinica 2019, 77 1239 (in Chinese). doi: 10.6023/A19080305
	(熊麟, 凡勇, 张凡, 化学学报, 2019, 77 1239.) doi: 10.6023/A19080305
[57]	Welsher, K.; Liu, Z.; Sherlock, S. P.; Robinson, J. T.; Chen, Z.; Daranciang, D.; Dai, H. J. Nat. Nanotechnol. 2009, 4 773. doi: 10.1038/nnano.2009.294 pmid: 19893526
[58]	Diao, S.; Hong, G. S.; Antaris, A. L.; Blackburn, J. L.; Cheng, K.; Cheng, Z.; Dai, H. J. Nano Res. 2015, 8 3027.
[59]	Wang, F.; Zhong, Y.; Bruns, O.; Liang, Y.; Dai, H. Nat. Photonics 2024, 18 535.
[60]	Chen, G.; Tian, F.; Zhang, Y.; Zhang, Y.; Li, C.; Wang, Q. Adv. Funct. Mater. 2014, 24 2481.
[61]	Naczynski, D. J.; Tan, M. C.; Zevon, M.; Wall, B.; Kohl, J.; Kulesa, A.; Chen, S.; Roth, C. M.; Riman, R. E.; Moghe, P. V. Nat. Commun. 2013, 4 2199. doi: 10.1038/ncomms3199 pmid: 23873342
[62]	Ren, F.; Ding, L.; Liu, H.; Huang, Q.; Zhang, H.; Zhang, L.; Zeng, J.; Sun, Q.; Li, Z.; Gao, M. Biomaterials 2018, 175 30.
[63]	Wang, R.; Li, X.; Zhou, L.; Zhang, F. Angew. Chem. Int. Ed. 2014, 53 12086. doi: 10.1002/anie.201407420 pmid: 25196421
[64]	Li, B.; Zhao, M.; Zhang, F. ACS Mater. Lett. 2020, 2 905.
[65]	Yu, G. T.; Luo, M. Y.; Li, H.; Chen, S.; Huang, B.; Sun, Z. J.; Cui, R.; Zhang, M. ACS Nano 2019, 13 12830.
[66]	Wang, T.; Wang, S.; Liu, Z.; He, Z.; Yu, P.; Zhao, M.; Zhang, H.; Lu, L.; Wang, Z.; Wang, Z.; Zhang, W.; Fan, Y.; Sun, C.; Zhao, D.; Liu, W.; Bünzli, J.-C. G.; Zhang, F. Nat. Mater. 2021, 20 1571.
[67]	Qi, J.; Sun, C.; Zebibula, A.; Zhang, H.; Kwok, R. T. K.; Zhao, X.; Xi, W.; Lam, J. W. Y.; Qian, J.; Tang, B. Z. Adv. Mater. 2018, 30, e1706856.
[68]	He, A.; Li, X.; Dai, Z.; Li, Q.; Zhang, Y.; Ding, M.; Wen, Z.-F.; Mou, Y.; Dong, H. J. Nanobiotechnol. 2023, 21 236.
[69]	Chang, Y. L.; Chen, H. R.; Xie, X. Y.; Wan, Y.; Li, Q. Q.; Wu, F. X.; Yang, R.; Wang, W.; Kong, X. G. Nat. Commun. 2023, 14 1079.
[70]	Chen, Z. H.; Wang, X.; Yang, M.; Ming, J.; Yun, B.; Zhang, L.; Wang, X.; Yu, P.; Xu, J.; Zhang, H.; Zhang, F. Angew. Chem. Int. Ed. 2023, 62, e202311883.
[71]	Tong, S.; Zhong, J.; Chen, X.; Deng, X.; Huang, J.; Zhang, Y.; Qin, M.; Li, Z.; Cheng, H.; Zhang, W.; Zheng, L.; Xie, W.; Qiu, P.; Wang, K. ACS Nano 2023, 17 3686.
[72]	Yang, Y.; Jiang, Q.; Zhang, F. Chem. Rev. 2024, 124 554. doi: 10.1021/acs.chemrev.3c00506 pmid: 37991799
[73]	Yang, M.; Gong, H.; Yang, D.; Feng, L.; Gai, S.; Zhang, F.; Ding, H.; He, F.; Yang, P. Chin. Chem. Lett. 2024, 35 108468.
[74]	Ren, F.; Jiang, Z.; Han, M.; Zhang, H.; Yun, B.; Zhu, H.; Li, Z. VIEW 2021, 2 20200128.
[75]	Fan, Y.; Zhang, F. Adv. Opt. Mater. 2019, 7 1801417.
[76]	Fan, Y.; Liu, L.; Zhang, F. Nano Today 2019, 25 68.
[77]	Wu, Z.; Ke, J.; Liu, Y.; Sun, P.; Hong, M. Acta Chim. Sinica 2022, 80 542 (in Chinese).
	(吴志芬, 柯建熙, 刘永升, 孙蓬明, 洪茂椿, 化学学报, 2022, 80 542.) doi: 10.6023/A21120571
[78]	Nannuri, S. H.; Kulkarni, S. D.; , K, S. C.; Chidangil, S.; George, S. D. RSC Adv. 2019, 9 9364.
[79]	Jin, G. Q.; Guo, L. J.; Zhang, J.; Gao, S.; Zhang, J. L. Top. Curr. Chem. 2022, 380 31.
[80]	Liu, Z. Y.; Liu, A. A.; Fu, H.; Cheng, Q. Y.; Zhang, M. Y.; Pan, M. M.; Liu, L. P.; Luo, M. Y.; Tang, B.; Zhao, W.; Kong, J.; Shao, X.; Pang, D. W. J. Am. Chem. Soc. 2021, 143 12867.
[81]	Li, Y.; Cai, Z.; Liu, S.; Zhang, H.; Wong, S. T. H.; Lam, J. W. Y.; Kwok, R. T. K.; Qian, J.; Tang, B. Z. Nat. Commun. 2020, 11 1255.
[82]	Zhu, X.; Liu, C.; Hu, Z.; Liu, H.; Wang, J.; Wang, Y.; Wang, X.; Ma, R.; Zhang, X.; Sun, H.; Liang, Y. Nano Res. 2020, 13 2570.
[83]	Sun, C.; Li, B.; Zhao, M.; Wang, S.; Lei, Z.; Lu, L.; Zhang, H.; Feng, L.; Dou, C.; Yin, D.; Xu, H.; Cheng, Y.; Zhang, F. J. Am. Chem. Soc. 2019, 141 19221.
[84]	Cosco, E. D.; Spearman, A. L.; Ramakrishnan, S.; Lingg, J. G. P.; Saccomano, M.; Pengshung, M.; Arús, B. A.; Wong, K. C. Y.; Glasl, S.; Ntziachristos, V.; Warmer, M.; McLaughlin, R. R.; Bruns, O. T.; Sletten, E. M. Nat. Chem. 2020, 12 1123.
[85]	Zhu, S.; Herraiz, S.; Yue, J.; Zhang, M.; Wan, H.; Yang, Q.; Ma, Z.; Wang, Y.; He, J.; Antaris, A. L.; Zhong, Y.; Diao, S.; Feng, Y.; Zhou, Y.; Yu, K.; Hong, G.; Liang, Y.; Hsueh, A. J.; Dai, H. Adv. Mater. 2018, 30, e1705799.
[86]	Meador, W. E.; Lin, E. Y.; Lim, I.; Friedman, H. C.; Ndaleh, D.; Shaik, A. K.; Hammer, N. I.; Yang, B.; Caram, J. R.; Sletten, E. M.; Delcamp, J. H. Nat. Chem. 2024, 16 970.
[87]	Cherukuri, P.; Bachilo, S. M.; Litovsky, S. H.; Weisman, R. B. J. Am. Chem. Soc. 2004, 126 15638. pmid: 15571374
[88]	Baghdasaryan, A.; Wang, F.; Ren, F.; Ma, Z.; Li, J.; Zhou, X.; Grigoryan, L.; Xu, C.; Dai, H. Nat. Commun. 2022, 13 5613. doi: 10.1038/s41467-022-33341-6 pmid: 36153336
[89]	Chang, B.; Li, D.; Ren, Y.; Qu, C.; Shi, X.; Liu, R.; Liu, H.; Tian, J.; Hu, Z.; Sun, T.; Cheng, Z. Nat. Biomed. Eng. 2022, 6 629.
[90]	Wegner, K. D.; Hildebrandt, N. Chem. Soc. Rev. 2015, 44 4792. doi: 10.1039/c4cs00532e pmid: 25777768
[91]	Xie, R.; Rutherford, M.; Peng, X. J. Am. Chem. Soc. 2009, 131 5691.
[92]	Huang, B.; Tang, T.; Liu, F.; Chen, S.-H.; Zhang, Z.-L.; Zhang, M.; Cui, R. Chin. Chem. Lett. 2024, 109694.
[93]	Shen, S.; Wang, Q. Chem. Mater. 2013, 25 1166.
[94]	Zebibula, A.; Alifu, N.; Xia, L.; Sun, C.; Yu, X.; Xue, D.; Liu, L.; Li, G.; Qian, J. Adv. Funct. Mater. 2018, 28 1703451.
[95]	Zhang, M.; Yue, J.; Cui, R.; Ma, Z.; Wan, H.; Wang, F.; Zhu, S.; Zhou, Y.; Kuang, Y.; Zhong, Y.; Pang, D.-W.; Dai, H. Proc. Natl. Acad. Sci. 2018, 115 6590.
[96]	Zheng, W.; Gao, G.; Deng, H.; Sun, T. Acta Chim. Sinica 2023, 81 763 (in Chinese).
	(郑文山, 高冠斌, 邓浩, 孙涛垒, 化学学报, 2023, 81 763.) doi: 10.6023/A23040128
[97]	Jeong, S.; Jung, Y.; Bok, S.; Ryu, Y. M.; Lee, S.; Kim, Y. E.; Song, J.; Kim, M.; Kim, S. Y.; Ahn, G. O.; Kim, S. Adv. Healthcare Mater. 2018, 7, e1800695.
[98]	Bruns, O. T.; Bischof, T. S.; Harris, D. K.; Franke, D.; Shi, Y.; Riedemann, L.; Bartelt, A.; Jaworski, F. B.; Carr, J. A.; Rowlands, C. J.; Wilson, M. W. B.; Chen, O.; Wei, H.; Hwang, G. W.; Montana, D. M.; Coropceanu, I.; Achorn, O. B.; Kloepper, J.; Heeren, J.; So, P. T. C.; Fukumura, D.; Jensen, K. F.; Jain, R. K.; Bawendi, M. G. Nat. Biomed. Eng. 2017, 1 0056.
[99]	Jiang, L.; Wang, K.; Qiu, L. Asian J. Pharm. Sci. 2022, 17 924.
[100]	Yin, B.; Liu, X.; Li, Z.; Ye, Z.; Wang, Y.; Yin, X.; Liu, S.; Song, G.; Huan, S.; Zhang, X.-B. Chin. Chem. Lett. 2024, 110119.
[101]	Sun, B.; Ma, R.; Wang, X.; Ma, S.; Li, W.; Liu, T.; Zhu, W.; Ji, Z.; Hettie, K. S.; Liu, C.; Liang, Y.; Zhu, S. VIEW 2024, 5 20230097.
[102]	Gui, Y.; Chen, K.; Sun, Y.; Tan, Y.; Luo, W.; Zhu, D.; Xiong, Y.; Yan, D.; Wang, D.; Tang, B. Z. Chin. J. Chem. 2023, 41 1249.
[103]	Liu, S.; Li, Y.; Kwok, R. T. K.; Lam, J. W. Y.; Tang, B. Z. Chem. Sci. 2021, 12 3427.
[104]	Xu, W.; Wang, D.; Tang, B. Z. Angew. Chem. Int. Ed. 2021, 60 7476.
[105]	Cheng, Y.; Sun, C.; Ou, X.; Liu, B.; Lou, X.; Xia, F. Chem. Sci. 2017, 8 4571. doi: 10.1039/c7sc00402h pmid: 28626568
[106]	Hu, Z.; Fang, C.; Li, B.; Zhang, Z.; Cao, C.; Cai, M.; Su, S.; Sun, X.; Shi, X.; Li, C.; Zhou, T.; Zhang, Y.; Chi, C.; He, P.; Xia, X.; Chen, Y.; Gambhir, S. S.; Cheng, Z.; Tian, J. Nat. Biomed. Eng. 2020, 4 259.
[107]	Carr, J. A.; Franke, D.; Caram, J. R.; Perkinson, C. F.; Saif, M.; Askoxylakis, V.; Datta, M.; Fukumura, D.; Jain, R. K.; Bawendi, M. G.; Bruns, O. T. Proc. Natl. Acad. Sci. 2018, 115 4465.
[108]	O'Connell, M. J.; Bachilo, S. M.; Huffman, C. B.; Moore, V. C.; Strano, M. S.; Haroz, E. H.; Rialon, K. L.; Boul, P. J.; Noon, W. H.; Kittrell, C.; Ma, J.; Hauge, R. H.; Weisman, R. B.; Smalley, R. E. Science 2002, 297 593. pmid: 12142535
[109]	Zhu, S.; Yang, Q.; Antaris, A. L.; Yue, J.; Ma, Z.; Wang, H.; Huang, W.; Wan, H.; Wang, J.; Diao, S.; Zhang, B.; Li, X.; Zhong, Y.; Yu, K.; Hong, G.; Luo, J.; Liang, Y.; Dai, H. Proc. Natl. Acad. Sci. 2017, 114 962.
[110]	Shi, W.-Q.; Zeng, L.; He, R.-L.; Han, X.-S.; Guan, Z.-J.; Zhou, M.; Wang, Q.-M. Science 2024, 383 326. doi: 10.1126/science.adk6628 pmid: 38236955
[111]	Schmidt, E. L.; Ou, Z.; Ximendes, E.; Cui, H.; Keck, C. H. C.; Jaque, D.; Hong, G. Nat. Rev. Methods Primers 2024, 4 23.
[112]	Zhong, Y.; Ma, Z.; Wang, F.; Wang, X.; Yang, Y.; Liu, Y.; Zhao, X.; Li, J.; Du, H.; Zhang, M.; Cui, Q.; Zhu, S.; Sun, Q.; Wan, H.; Tian, Y.; Liu, Q.; Wang, W.; Garcia, K. C.; Dai, H. Nat. Biotechnol. 2019, 37 1322.
[113]	Naczynski, D. J.; Sun, C.; Türkcan, S.; Jenkins, C.; Koh, A. L.; Ikeda, D.; Pratx, G.; Xing, L. Nano Lett. 2015, 15 96. doi: 10.1021/nl504123r pmid: 25485705
[114]	Cao, X.; Jiang, S.; Jia, M. J.; Gunn, J. R.; Miao, T.; Davis, S. C.; Bruza, P.; Pogue, B. W. J. Biomed. Opt. 2018, 24 1. doi: 10.1117/1.JBO.24.5.051405 pmid: 30468044
[115]	Knez, D.; Hanninen, A. M.; Prince, R. C.; Potma, E. O.; Fishman, D. A. Light Sci. Appl. 2020, 9 125.
[116]	Kim, T.; O'Brien, C.; Choi, H. S.; Jeong, M. Y. Appl. Spectrosc. Rev. 2018, 53 349.
[117]	Wang, F.; Qu, L.; Ren, F.; Baghdasaryan, A.; Jiang, Y.; Hsu, R.; Liang, P.; Li, J.; Zhu, G.; Ma, Z.; Dai, H. Proc. Natl. Acad. Sci. 2022, 119, e2123111119.
[118]	Chen, Y.; Yang, Y.; Zhang, F. Nat. Protoc. 2024, 19 2386.
[119]	Bonis-O'Donnell, J. T. D.; Page, R. H.; Beyene, A. G.; Tindall, E. G.; McFarlane, I. R.; Landry, M. P. Adv. Funct. Mater. 2017, 27 1702112.
[120]	Huisken, J.; Swoger, J.; Del Bene, F.; Wittbrodt, J.; Stelzer, E. H. Science 2004, 305 1007. doi: 10.1126/science.1100035 pmid: 15310904
[121]	Wang, F.; Wan, H.; Ma, Z.; Zhong, Y.; Sun, Q.; Tian, Y.; Qu, L.; Du, H.; Zhang, M.; Li, L.; Ma, H.; Luo, J.; Liang, Y.; Li, W. J.; Hong, G.; Liu, L.; Dai, H. Nat. Methods 2019, 16 545.
[122]	Pei, P.; Chen, Y.; Sun, C.; Fan, Y.; Yang, Y.; Liu, X.; Lu, L.; Zhao, M.; Zhang, H.; Zhao, D.; Liu, X.; Zhang, F. Nat. Nanotechnol. 2021, 16 1011.
[123]	Lu, L.; Li, B.; Ding, S.; Fan, Y.; Wang, S.; Sun, C.; Zhao, M.; Zhao, C.-X.; Zhang, F. Nat. Commun. 2020, 11 4192.
[124]	Zhu, X.; Liu, X.; Zhang, H.; Zhao, M.; Pei, P.; Chen, Y.; Yang, Y.; Lu, L.; Yu, P.; Sun, C.; Ming, J.; Abraham, I. M.; El-Toni, A. M.; Khan, A.; Zhang, F. Angew. Chem. Int. Ed. 2021, 60 23545. doi: 10.1002/anie.202108124 pmid: 34487416
[125]	Yang, Y.; Wang, S.; Lu, L.; Zhang, Q.; Yu, P.; Fan, Y.; Zhang, F. Angew. Chem. Int. Ed. 2020, 59 18380.
[126]	Xu, H.; Yang, Y.; Lu, L.; Yang, Y.; Zhang, Z.; Zhao, C.-X.; Zhang, F.; Fan, Y. Anal. Chem. 2022, 94 3661.
[127]	Cao, C.; Jin, Z.; Shi, X.; Zhang, Z.; Xiao, A.; Yang, J.; Ji, N.; Tian, J.; Hu, Z. IEEE Trans. Biomed. Eng. 2022, 69 2404.
[128]	Qu, Q.; Nie, H.; Hou, S.; Wang, F.; He, K.; Deng, P.; Chen, S.; Zhang, Z.; Chi, C.; Hu, Z.; Shan, H.; Tian, J. Eur. J. Nucl. Med. Mol. Imaging 2022, 49 4752.
[129]	Smith, A. M.; Mancini, M. C.; Nie, S. Nat. Nanotechnol. 2009, 4 710.
[130]	Huang, J.; Su, L.; Xu, C.; Ge, X.; Zhang, R.; Song, J.; Pu, K. Nat. Mater. 2023, 22 1421.

近红外二区荧光探针在活体多重成像中的研究进展

Research Progress on Fluorescent Probes in the Second Near-Infrared Window for In Vivo Multiplexed Imaging

RichHTML

PDF

可视化

摘要/Abstract

引用此文

分享此文

图/表 7

参考文献 130

相关文章 15

编辑推荐

相关统计

本文评价

[1]	刘童, 皮慧慧, 陈冰昆, 张小玲. 近红外二区硫系银量子点制备方法及癌症诊疗应用研究进展[J]. 化学学报, 2024, 82(9): 1001-1012.
[2]	武虹乐, 郭锐, 迟涵文, 唐永和, 宋思睿, 葛恩香, 林伟英. 喹啉基粘度荧光探针的合成及其检测应用[J]. 化学学报, 2023, 81(8): 905-911.
[3]	贺晓梦, 袁方, 张素雅, 张健健. 基于尼罗红类ONOO^–近红外荧光探针的开发及其成像应用[J]. 化学学报, 2023, 81(11): 1515-1521.
[4]	孙丽, 王亚静, 李涛, 郭英姝, 张书圣. 金纳米笼探针用于线粒体成像和光热损伤细胞^★[J]. 化学学报, 2023, 81(10): 1301-1310.
[5]	宋思睿, 唐永和, 孙良广, 郭锐, 姜冠帆, 林伟英. 基于香豆素荧光团的新型极性检测荧光探针的开发及其成像应用[J]. 化学学报, 2022, 80(9): 1217-1222.
[6]	吴志芬, 柯建熙, 刘永升, 孙蓬明, 洪茂椿. 稀土近红外二区纳米荧光影像探针及其生物医学应用^※[J]. 化学学报, 2022, 80(4): 542-552.
[7]	王其, 夏辉, 熊炎威, 张新敏, 蔡杰, 陈冲, 高逸聪, 陆峰, 范曲立. 调控供电子策略简易制备近红外二区有机小分子光学诊疗试剂[J]. 化学学报, 2022, 80(11): 1485-1493.
[8]	李勇, 王栩, 解希雷, 张建, 唐波. 一氧化碳有机荧光探针和光控释放剂研究进展[J]. 化学学报, 2021, 79(1): 36-44.
[9]	桑若愚, 许兴鹏, 王其, 范曲立, 黄维. 近红外二区有机小分子荧光探针[J]. 化学学报, 2020, 78(9): 901-915.
[10]	罗兴蕊, 陈敏文, 杨晴来. 近红外二区活体成像技术及其应用研究进展[J]. 化学学报, 2020, 78(5): 373-381.
[11]	贾伊祎, 王文杰, 梁玲, 袁荃. 核酸功能化稀土基纳米材料在生物检测中的应用[J]. 化学学报, 2020, 78(11): 1177-1184.
[12]	刘红文, 朱隆民, 娄霄峰, 袁林, 张晓兵. 用于细胞和组织中弗林蛋白酶特异性成像的双光子荧光探针研究[J]. 化学学报, 2020, 78(11): 1240-1245.
[13]	郑斌, 程盛, 董华泽, 朱金苗, 韩钰, 杨亮, 胡进明. 一氧化氮响应性高分子荧光探针的构筑及其细胞内成像应用[J]. 化学学报, 2020, 78(10): 1089-1095.
[14]	王英美, 朱道明, 杨阳, 张珂, 张修珂, 吕明珊, 胡力, 丁帅杰, 王亮. 快速合成Bi@ZIF-8复合纳米材料用于近红外二区光热治疗以及可控药物释放[J]. 化学学报, 2020, 78(1): 76-81.
[15]	陈凯, 韩百川, 嵇思鑫, 孙瑾, 高振忠, 侯贤锋. 一种可用于直接检测空气中异氰酸酯的比率型荧光探针[J]. 化学学报, 2019, 77(4): 365-370.