连续流聚合诱导自组装

doi:10.6023/A26030073

综述

连续流聚合诱导自组装

李牧舟^a, 徐婷婷^a, 胡欣^b,*, 孙冰^c,*, 朱宁^a,*

^a南京工业大学生物与制药工程学院材料化学工程国家重点实验室南京 211800;
^b南京工业大学材料科学与工程学院南京 211800;
^c中石化安全工程研究院有限公司化学品安全全国重点实验室青岛 266000

投稿日期:2026-03-12
作者简介:胡欣,西安交通大学材料科学与工程博士,南京工业大学材料科学与工程学院教授. 主要从事功能高分子材料开发及微化工制备研究,加入南工至今以第一或通讯作者(含共同作者)在ACS Appl. Mater. Interfaces、ACS Macro Lett.、ACS Appl. Polym. Mater.、Chem. Eng. J.、Carbohydr. Polym.等期刊发表论文40余篇,主持国家自然科学基金面上项目和青年项目各1项、企业委托开发项目3项,获中国化工学会基础研究成果奖一等奖,入选江苏省科技副总.孙冰,美国加州理工学院博士,中石化安全工程研究院化工过程安全研究所所长、研究员,主要从事化工过程安全技术开发、新型本质安全化工艺与装备开发工作; 在Angew. Chem. Int. Ed等期刊发表SCI论文70余篇; 获国内外授权发明专利80余件; 研究成果曾获化工学会基础研究一等奖、石化联合会科技进步一等奖等科技奖励; 担任国家重点研发计划首席科学家,获得侯德榜化工科学技术创新奖等荣誉.朱宁,浙江大学高分子化学与物理专业博士,南京工业大学生物与制药工程学院教授; 主要研究化工新材料绿色制造; 加入南工以来作为第一或通讯作者(含共同)在Nat. Mater.、Angew. Chem. Int. Ed.、Adv. Funct. Mater.、AIChE J.、ACS Appl. Mater. Interfaces等期刊发表论文50余篇; 授权中国发明专利50余件、美国专利5件; 主持科技部项目课题1项/子课题1项、国家自然科学基金面上项目3项/青年项目1项、企业委托开发项目6项,获省部级科研奖励6项.
基金资助:
国家自然科学基金(22478188, 22278223, 22278205)和化学品安全全国重点实验室开放课题(SKLCS-2025008).

Continuous-Flow Polymerization-Induced Self-Assembly

Li Muzhou^a, Xu Tingting^a, Hu Xin^b,*, Sun Bing^c,*, Zhu Ning^a,*

^aCollege of Biotechnology and Pharmaceutical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China;
^bCollege of Materials Science and Engineering, Nanjing Tech University, Nanjing, Jiangsu 211800, China;
^cSINOPEC Research Institute of Safety Engineering Co., Ltd., State Key Laboratory of Chemical Safety, Qingdao, Shandong 266000, China

Received:2026-03-12
Contact: ^*E-mail: xinhu@njtech.edu.cn, sunb.qday@sinopec.com, ningzhu@njtech.edu.cn
Supported by:
National Natural Science Foundation of China (22478188, 22278223, 22278205) and R&D Program of State Key Laboratory of Chemical Safety (SKLCS-2025008).

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摘要/Abstract

聚合诱导自组装(PISA)作为高效制备高固含量、形貌多样聚合物纳米颗粒的新策略, 在高分子合成化学等领域引起了广泛的研究兴趣. 相较于传统釜式间歇反应, 基于微反应器的流动化学与聚合诱导自组装相结合, 展示出更快的反应速度、独特的高级形貌、更好的与新技术耦合赋能等诸多优势. 本文聚焦连续流聚合诱导自组装, 分别介绍了连续流热引发PISA、连续流光诱导PISA、耦合新技术PISA的研究进展, 对相关领域存在的机遇与挑战进行了探讨和展望, 希望对流动化学和聚合诱导自组装的发展提供借鉴.

关键词: 连续流, 聚合诱导自组装, 嵌段共聚物, 纳米颗粒, 可控聚合

As an efficient strategy for preparing polymer nano-objects with high solid content and diverse morphologies, polymerization-induced self-assembly (PISA) has attracted growing research interest in the fields such as polymer synthetic chemistry. Compared with the traditional batch reactions, the combination of microreactor-based flow chemistry with PISA offers unique advantages, including but not limited to accelerated reaction rates, access to higher-order morphologies, and easy to integrations of new technologies. This review focuses on continuous-flow PISA, covering continuous-flow thermal-initiated PISA, continuous-flow photo-induced PISA, and continuous-flow PISA integrated with emerging technologies. Opportunities and challenges in the related topics are proposed and discussed with the aim to promote the development of flow chemistry and polymerization-induced self-assembly.

Key words: Continuous-flow, Polymerization-induced self-assembly, Block copolymer, Nano-object, controlled polymerization

引用此文

李牧舟, 徐婷婷, 胡欣, 孙冰, 朱宁. 连续流聚合诱导自组装[J]. 化学学报, doi: 10.6023/A26030073.

Li Muzhou, Xu Tingting, Hu Xin, Sun Bing, Zhu Ning. Continuous-Flow Polymerization-Induced Self-Assembly[J]. Acta Chimica Sinica, doi: 10.6023/A26030073.

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