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2016 , Vol. 74 >Issue 9: 713 - 725

DOI: https://doi.org/10.6023/A16030147

综述

胍类抗菌聚合物的构建及应用

  • 彭开美 ,
  • 丁伟 ,
  • 涂伟萍 ,
  • 胡剑青 ,
  • Liu Chao ,
  • Yang Jian
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  • a 华南理工大学化学化工学院 广东省绿色化学产品技术重点实验室 广东 广州 510640;
    b Aleo BME, Inc. 200 Innovation Blvd, Suite 210A, State College, PA 16803, USA

收稿日期: 2016-03-26

  网络出版日期: 2016-08-10

基金资助

项目受国家自然科学基金（50903031）和广州市对外合作项目（2012J5100043）资助.

收起

Construction of Guanidinium-rich Polymers and Their Applications

  • Peng Kaimei ,
  • Ding Wei ,
  • Tu Weiping ,
  • Hu Jianqing ,
  • Liu Chao ,
  • Yang Jian
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  • a Guangdong Provincial Key Laboratory for Green Chemical Product Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, Guangdong, China;
    b Aleo BME, Inc. 200 Innovation Blvd, Suite 210A, State College, PA 16803, USA

Received date: 2016-03-26

  Online published: 2016-08-10

Supported by

Project supported by the National Natural Science Foundation of China (50903031) and the International Science & Technology Cooperation Program of Guangzhou (2012J5100043).

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摘要

抗菌与大众生活密切相关，药物或基因的有效传送对于现代医疗来说是个不可或缺的手段，而含胍聚合物在这两个方向都有其独特的性能，如胍类聚合物的杀菌方式是通过非特异性（静电）相互作用来实现的，从生物进化的角度来看，细菌很难对其产生抗药性. 其次，胍基与细胞膜磷脂中的磷酸根“牢固”的双氢键相互作用，使其在药物或基因的转运方面表现优秀. 同时，含胍聚合物对哺乳动物细胞相应低的或无毒性也为其应用扫清了障碍. 因此，本文基于现有的文献资料，归纳了含胍聚合物的构建方式和方法、综述了其在微生物抑制、药物或基因转运领域的应用.

关键词： 含胍聚合物; 微生物抑制; 药物传递; 基因转运

本文引用格式

彭开美 , 丁伟 , 涂伟萍 , 胡剑青 , Liu Chao , Yang Jian . 胍类抗菌聚合物的构建及应用[J]. 化学学报, 2016 , 74(9) : 713 -725 . DOI: 10.6023/A16030147

Abstract

Antimicrobial is closely related to public life and efficient delivery of drug and gene is an indispensable means for the modern medicine. However, guanidinium-rich polymer has particular function in antimicrobial and delivery, such as the bactericidal mode of guanidinium-rich polymer is the non-specific interaction—electrostatic interaction, which is the driving force of the movement for the process of guanidinium-rich polymer getting close to the cell membrane of microbes, and from the perspective of biological evolution, which make bacterial hard to evolve resistance. On the other hand, the tight double-hydrogen bonded structure between guanidino and phosphate in the cell membrane phospholipids is the foundation for guanidinium-rich polymer exhibiting excellent performance on delivery, which will be an important grasp for the guanidinium-rich polymer and its carrying molecules entering the mammalian cell membrane. Moreover, relatively lower toxicity or nontoxicity of guanidinium-rich polymer for the mammalian cells remove the obstacle of applications. Therefore, this paper is based on available literature, sums up the fabrication methods of guanidinium-rich polymer, reviews the applications in microbial inhibition and delivery of drug or gene.

Key words： guanidinium-rich polymer; microbial inhibition; drug delivery; gene delivery

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