Acta Chimica Sinica ›› 2015, Vol. 73 ›› Issue (12): 1283-1293.DOI: 10.6023/A15040295 Previous Articles     Next Articles

Special Issue: 碳氢键官能团化


过渡金属催化的惰性碳氢键卤化反应研究进展 2017 Awarded

廖港, 史炳锋   

  1. 浙江大学化学系 杭州 310027
  • 投稿日期:2015-04-29 发布日期:2015-09-15
  • 通讯作者: 史炳锋
  • 基金资助:


Recent Advances on Transition-Metal-Catalyzed Halogenation of Unactivated C-H Bonds

Liao Gang, Shi Bingfeng   

  1. Department of Chemistry, Zhejiang University, Hangzhou 310027
  • Received:2015-04-29 Published:2015-09-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China(No. 21422206).

Halogenation is one of the most important reactions in organic synthesis. Recently, transition-mental-catalyzed C-H halogenation has emerged as a powerful and economical strategy for the synthesis of organohalides. In this review, we summarize recent advances on transition-metal-catalyzed halogenation of unactivated C-H bonds, according to the types of transition metals(palladium, copper, rhodium, ruthenium, and cobalt), the scope of reactions and mechanism. Finally, the limitations and perspectives on C-H halogenation are also described.

Key words: transition-metal, C-H activation, halogenation, organohalides