Acta Chimica Sinica ›› 2022, Vol. 80 ›› Issue (7): 1010-1020.DOI: 10.6023/A22010042 Previous Articles     Next Articles



高至亮, 李梦琦, 郝京诚, 崔基炜*()   

  1. 山东大学胶体与界面化学教育部重点实验室 济南 250100
  • 投稿日期:2022-01-22 发布日期:2022-05-20
  • 通讯作者: 崔基炜
  • 作者简介:

    高至亮, 博士, 2020年博士毕业于山东大学胶体与界面化学教育部重点实验室, 主要从事功能性生物高分子材料的合成、组装、物理化学性质调控及在生物医学领域的应用研究.

    李梦琦, 山东大学胶体与界面化学教育部重点实验室硕博连读研究生, 研究方向为胶体粒子的可控制备、性能调控及其在生物领域中的应用.

    郝京诚, 教授, 博士生导师. 1995 年博士毕业于中国科学院兰州化学物理研究所, 1997~2003 年分别在日本、德国和美国从事博士后研究, 主要研究方向是胶体与界面化学及其相关应用.

    崔基炜, 教授, 博士生导师. 2010 年博士毕业于山东大学胶体与界面化学教育部重点实验室, 2010 至2016 年在墨尔本大学从事博士后研究工作. 研究领域主要包括高分子胶体、界面组装与调控、药物和疫苗递送等.

  • 基金资助:
    国家自然科学基金(21872085); 国家自然科学基金(22102088); 山东省自然科学基金(ZR202102240400)

Tuning the Mechanical Properties of Colloid Particles for Drug Delivery

Zhiliang Gao, Mengqi Li, Jingcheng Hao, Jiwei Cui()   

  1. Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan 250100
  • Received:2022-01-22 Published:2022-05-20
  • Contact: Jiwei Cui
  • Supported by:
    National Natural Science Foundation of China(21872085); National Natural Science Foundation of China(22102088); Natural Science Foundation of Shandong Province(ZR202102240400)

Colloidal particles are the most common carriers of anticancer drugs. Although various colloidal particles as carriers have been reported, it is still challenging to enhance the drug delivery efficacy. It has been proved that physicochemical properties (e.g., size, shape, structure, and surface chemistry) of colloidal particles play an important role in drug delivery processes, while the influence of the mechanical property of colloidal particles on the drug delivery process is rarely reported and reviewed. In this review, we summarize the preparation and characterization of colloidal particles with different mechanical properties. The influence of the mechanical properties of colloidal particles on blood circulation, tumor accumulation and penetration as well as cell internalization are also highlighted. Furthermore, the challenges and future directions in this field are discussed, which is helpful to understand the influence of mechanical property on the design of colloidal particles as carriers to improve the drug delivery efficacy and bioavailability of nanomedicines.

Key words: colloid particle, mechanical property, bio-nano interaction, drug delivery, nanocarrier