Tuning the Mechanical Properties of Colloid Particles for Drug Delivery

doi:10.6023/A22010042

Acta Chimica Sinica ›› 2022, Vol. 80 ›› Issue (7): 1010-1020.DOI: 10.6023/A22010042 Previous Articles Next Articles

Review

胶体粒子的机械性能调控及其在药物递送中的应用

高至亮, 李梦琦, 郝京诚, 崔基炜^*()

山东大学胶体与界面化学教育部重点实验室济南 250100

投稿日期:2022-01-22 发布日期:2022-05-20
通讯作者: 崔基炜

作者简介:

高至亮, 博士, 2020年博士毕业于山东大学胶体与界面化学教育部重点实验室, 主要从事功能性生物高分子材料的合成、组装、物理化学性质调控及在生物医学领域的应用研究.

李梦琦, 山东大学胶体与界面化学教育部重点实验室硕博连读研究生, 研究方向为胶体粒子的可控制备、性能调控及其在生物领域中的应用.

郝京诚, 教授, 博士生导师. 1995 年博士毕业于中国科学院兰州化学物理研究所, 1997~2003 年分别在日本、德国和美国从事博士后研究, 主要研究方向是胶体与界面化学及其相关应用.

崔基炜, 教授, 博士生导师. 2010 年博士毕业于山东大学胶体与界面化学教育部重点实验室, 2010 至2016 年在墨尔本大学从事博士后研究工作. 研究领域主要包括高分子胶体、界面组装与调控、药物和疫苗递送等.

基金资助:
国家自然科学基金(21872085); 国家自然科学基金(22102088); 山东省自然科学基金(ZR202102240400)

Tuning the Mechanical Properties of Colloid Particles for Drug Delivery

Zhiliang Gao, Mengqi Li, Jingcheng Hao, Jiwei Cui()

Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan 250100

Received:2022-01-22 Published:2022-05-20
Contact: Jiwei Cui
Supported by:
National Natural Science Foundation of China(21872085); National Natural Science Foundation of China(22102088); Natural Science Foundation of Shandong Province(ZR202102240400)

Colloidal particles are the most common carriers of anticancer drugs. Although various colloidal particles as carriers have been reported, it is still challenging to enhance the drug delivery efficacy. It has been proved that physicochemical properties (e.g., size, shape, structure, and surface chemistry) of colloidal particles play an important role in drug delivery processes, while the influence of the mechanical property of colloidal particles on the drug delivery process is rarely reported and reviewed. In this review, we summarize the preparation and characterization of colloidal particles with different mechanical properties. The influence of the mechanical properties of colloidal particles on blood circulation, tumor accumulation and penetration as well as cell internalization are also highlighted. Furthermore, the challenges and future directions in this field are discussed, which is helpful to understand the influence of mechanical property on the design of colloidal particles as carriers to improve the drug delivery efficacy and bioavailability of nanomedicines.

Key words: colloid particle, mechanical property, bio-nano interaction, drug delivery, nanocarrier

Cite this article

Zhiliang Gao, Mengqi Li, Jingcheng Hao, Jiwei Cui. Tuning the Mechanical Properties of Colloid Particles for Drug Delivery[J]. Acta Chimica Sinica, 2022, 80(7): 1010-1020.

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Fig. & Tab. 8

Figure 1. Schematic illustration of (a) hydrogel nanoparticles (NPs), (b) nanocapsules and (c) liposome NPs with different stiffness

Figure 2. (a) Schematic illustration of the preparation of PGA-CpG particles via templating MS particles; (b) molecular structure of PGA-CpG; (c) Young’s modulus of PGA-CpG particles as a function of cross-linker concentration; (d) fluorescence microscopy and TEM images of the PGA-CpG particles[33]

Figure 3. (a) A schematic diagram of a core-shell PLGA-lipid NP; (b) cryo-TEM images of a Lip-F1275% NP (left), a PLGA70-Lip-F1275% NP (middle), and a PLGA160-Lip-F1275% NP (right), scale bar: 100 nm; (c) fluorescence intensity and (d) Young’s modulus values of Lip-F1275%, PLGA70-Lip-F1275%, and PLGA160-Lip-F1275% NPs (n=3); (e) AFM images of Lip-F1275% NPs, PLGA70-Lip-F1275% NPs, and PLGA160-Lip-F1275% NPs and the corresponding deformation images of the NPs after being subjected to forces of different magnitudes, scale bar: 200 nm[55]

Figure 4. (a) A typical force vs. distance profile; (b) formula of Young’s modulus based on DMT model; (c) formula of dissipation energy

Figure 5. (a) Schemes showing hard and soft pCB particles to pass through micro pores; (b) in vivo blood circulation profiles of pCB particles with different cross-linking densities[36]; (c) macrophage internalization of DNPs with different stiffness; (d) quantification of the number of particles internalized per cell for the different DPN geometries and mechanical properties[66]; (e) a microfluidic model mimicking aspects of blood capillaries; (f) microscopy images of particles with different stiffness and RBCs passing through the microfluidic capillaries[34]

Figure 6. (a) Scheme for the preparation of DPNs; (b) Young's modulus analysis for soft and rigid DPNs; (c) DPN accumulation in the tumor microvasculature[37]; (d) biodistribution of RBCMs 2 h postdosing[38]; (e) biodistribution of pCB NPs with varying stiffness 48 h post injection[36]

Figure 7. (a) Schematic illustration for the synthesis of silica nanocapsules with controllable mechanical property; (b) Young’s moduli of TEVS-30 h and TEOS-40 h silica capsules; (c) schematic illustration showing the penetration of stiff and soft nanocapsules in the 3D tumor spheroids[45]; (d) schematic illustration of the penetration of nanovesicles with low, intermediate and high stiffness in the 3D tumor spheroids[52]

Figure 8. (a) Young’s modulus of P-L and P-W-L NPs; (b) MD simulations of rigidity-governed cellular internalization[54]; (c) Young’s moduli of NLP and NLG; (d) cell internalization pathway influenced by particle stiffness[56]; (e) Young’s modulus of CGNPs calculated from Hertz model; (f) intracellular uptake of CGNPs after 4 h incubation[83]

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胶体粒子的机械性能调控及其在药物递送中的应用

Tuning the Mechanical Properties of Colloid Particles for Drug Delivery

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[3]	Ruomei Liu, Yanhui Feng, Zhuo Li, Shan Lu, Tianyong Guan, Xingjun Li, Yan Liu, Zhuo Chen, Xueyuan Chen. A Novel Near-infrared Responsive Lanthanide Upconversion Nanoplatform for Drug Delivery Based on Photocleavage of Cypate^※ [J]. Acta Chimica Sinica, 2022, 80(4): 423-427.
[4]	Zheng Cai, Yingwen Zhang, Liping Jiang, Junjie Zhu. The Construction and Application of Mn₃O₄/DOX@Lip Nano-drug Delivery System Based on Fenton-Like Reaction [J]. Acta Chimica Sinica, 2021, 79(4): 481-489.
[5]	Hua Yue, Guanghui Ma. Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect [J]. Acta Chimica Sinica, 2021, 79(10): 1244-1256.
[6]	Qi Ye, Ren Shuangsong, Che Ying, Ye Junwei, Ning Guiling. Research Progress of Metal-Organic Frameworks Based Antibacterial Materials [J]. Acta Chimica Sinica, 2020, 78(7): 613-624.
[7]	Zhang Liuwei, Chen Qixian, Wang Jingyun. Advances in Reactive Oxygen Species Responsive Anti-cancer Prodrugs [J]. Acta Chimica Sinica, 2020, 78(7): 642-656.
[8]	Zhao Weichen, Xu Xin, Bai Huijuan, Zhang Jin, Lu Shanfu, Xiang Yan. Self-crosslinked Polyethyleneimine-polysulfone Membrane for High Temperature Proton Exchange Membrane [J]. Acta Chimica Sinica, 2020, 78(1): 69-75.
[9]	Zeng Jinyue, Wang Xiaoshuang, Zhang Xianzheng, Zhuo Renxi. Research Progress in Functional Metal-Organic Frameworks for Tumor Therapy [J]. Acta Chimica Sinica, 2019, 77(11): 1156-1163.
[10]	Zhang Bei, Chang Baisong, Sun Taolei. Synthesis and Study of Hypoxia-Responsive Micelles Based on Hyaluronic Acid [J]. Acta Chim. Sinica, 2018, 76(1): 35-42.
[11]	Zhang Liuwei, Qian Ming, Wang Jingyun. Progress in Research of Photo-controlled Drug Delivery Systems [J]. Acta Chim. Sinica, 2017, 75(8): 770-782.
[12]	Peng Kaimei, Ding Wei, Tu Weiping, Hu Jianqing, Liu Chao, Yang Jian. Construction of Guanidinium-rich Polymers and Their Applications [J]. Acta Chim. Sinica, 2016, 74(9): 713-725.
[13]	Zhang Shaofei, Yang Jiandong, Liu Mingzhu, Lü Shaoyu, Gao Chunmei, Wu Can, Zhu Zhaoyan. Synthesis of Peptide Dendrimers and Their Application in the Drug Delivery System [J]. Acta Chim. Sinica, 2016, 74(5): 401-409.
[14]	Wang Xin, Tan Lili, Yang Yingwei. Controlled Drug Release Systems Based on Mesoporous Silica Capped by Gold Nanoparticles [J]. Acta Chim. Sinica, 2016, 74(4): 303-311.
[15]	Zhao Li, Ding Jianxun, Xiao Chunsheng, Chen Xuesi, Gai Guangqing, Wang Liyan. Poly(L-glutamic acid) Microsphere: Preparation and Application in Oral Drug Controlled Release [J]. Acta Chimica Sinica, 2015, 73(1): 60-65.